Guan Q - Search Results

1

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway.

Xu J, Han M, Shen J, Guan Q, Bai Z, Lang B, Zhang H, Li Z, Zuo D, Zhang W, Wu Y. Xu J, et al. Among authors: guan q. Cancer Lett. 2016 Dec 1;383(1):9-17. doi: 10.1016/j.canlet.2016.09.011. Epub 2016 Sep 28. Cancer Lett. 2016. PMID: 27693458

2

Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors.

Guan Q, Cheng Z, Ma X, Wang L, Feng D, Cui Y, Bao K, Wu L, Zhang W. Guan Q, et al. Eur J Med Chem. 2014 Oct 6;85:508-16. doi: 10.1016/j.ejmech.2014.08.014. Epub 2014 Aug 6. Eur J Med Chem. 2014. PMID: 25113879

3

Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4.

Guan Q, Yang F, Guo D, Xu J, Jiang M, Liu C, Bao K, Wu Y, Zhang W. Guan Q, et al. Eur J Med Chem. 2014 Nov 24;87:1-9. doi: 10.1016/j.ejmech.2014.09.046. Epub 2014 Sep 16. Eur J Med Chem. 2014. PMID: 25233100

4

Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities.

Guan Q, Han C, Zuo D, Zhai M, Li Z, Zhang Q, Zhai Y, Jiang X, Bao K, Wu Y, Zhang W. Guan Q, et al. Eur J Med Chem. 2014 Nov 24;87:306-15. doi: 10.1016/j.ejmech.2014.09.071. Epub 2014 Sep 28. Eur J Med Chem. 2014. PMID: 25262051

5

Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.

Guan Q, Zuo D, Jiang N, Qi H, Zhai Y, Bai Z, Feng D, Yang L, Jiang M, Bao K, Li C, Wu Y, Zhang W. Guan Q, et al. Bioorg Med Chem Lett. 2015 Feb 1;25(3):631-4. doi: 10.1016/j.bmcl.2014.12.004. Epub 2014 Dec 8. Bioorg Med Chem Lett. 2015. PMID: 25529737

6

3-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole (G-1103), a novel combretastatin A-4 analog, induces G2/M arrest and apoptosis by disrupting tubulin polymerization in human cervical HeLa cells and fibrosarcoma HT-1080 cells.

Zuo D, Guo D, Jiang X, Guan Q, Qi H, Xu J, Li Z, Yang F, Zhang W, Wu Y. Zuo D, et al. Among authors: guan q. Chem Biol Interact. 2015 Feb 5;227:7-17. doi: 10.1016/j.cbi.2014.12.016. Epub 2014 Dec 18. Chem Biol Interact. 2015. PMID: 25529822

7

Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents.

Xu Q, Wang Y, Xu J, Sun M, Tian H, Zuo D, Guan Q, Bao K, Wu Y, Zhang W. Xu Q, et al. Among authors: guan q. ACS Med Chem Lett. 2016 Oct 17;7(12):1202-1206. doi: 10.1021/acsmedchemlett.6b00252. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994764 Free PMC article.

8

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity.

Sun M, Xu Q, Xu J, Wu Y, Wang Y, Zuo D, Guan Q, Bao K, Wang J, Wu Y, Zhang W. Sun M, et al. Among authors: guan q. PLoS One. 2017 Mar 23;12(3):e0174006. doi: 10.1371/journal.pone.0174006. eCollection 2017. PLoS One. 2017. PMID: 28333984 Free PMC article.

9

Methyl 5-[(1H-indol-3-yl)selanyl]-1H-benzoimidazol-2-ylcarbamate (M-24), a novel tubulin inhibitor, causes G2/M arrest and cell apoptosis by disrupting tubulin polymerization in human cervical and breast cancer cells.

Zuo D, Jiang X, Han M, Shen J, Lang B, Guan Q, Bai Z, Han C, Li Z, Zhang W, Wu Y. Zuo D, et al. Among authors: guan q. Toxicol In Vitro. 2017 Aug;42:139-149. doi: 10.1016/j.tiv.2017.04.019. Epub 2017 Apr 13. Toxicol In Vitro. 2017. PMID: 28412508

10

5-(Furan-2-yl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one oxime (6f), a new synthetic compound, causes human ﬁbrosarcoma HT-1080 cell apoptosis by disrupting tubulin polymerisation and inducing G2/M arrest.

Zuo D, Pang L, Shen J, Guan Q, Bai Z, Zhang H, Li Y, Lu G, Zhang W, Wu Y. Zuo D, et al. Among authors: guan q. Int J Oncol. 2017 Jun;50(6):2069-2078. doi: 10.3892/ijo.2017.3963. Epub 2017 Apr 18. Int J Oncol. 2017. PMID: 28440465

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