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Metformin Activates AMPK through the Lysosomal Pathway.
Zhang CS, Li M, Ma T, Zong Y, Cui J, Feng JW, Wu YQ, Lin SY, Lin SC. Zhang CS, et al. Among authors: li m. Cell Metab. 2016 Oct 11;24(4):521-522. doi: 10.1016/j.cmet.2016.09.003. Cell Metab. 2016. PMID: 27732831 Free article. No abstract available.
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC. Zhang CS, et al. Among authors: li m, li ty. Cell Metab. 2014 Sep 2;20(3):526-40. doi: 10.1016/j.cmet.2014.06.014. Epub 2014 Jul 4. Cell Metab. 2014. PMID: 25002183 Free article.
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC. Zhang CS, et al. Among authors: li m, li ty. Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19. Nature. 2017. PMID: 28723898 Free PMC article.
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.
Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC. Li M, et al. Among authors: li y, li x. Cell Metab. 2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13. Cell Metab. 2019. PMID: 31204282 Free PMC article.
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer.
Wang Y, Zhang L, Wei Y, Huang W, Li L, Wu AA, Dastur A, Greninger P, Bray WM, Zhang CS, Li M, Lian W, Hu Z, Wang X, Liu G, Yao L, Guh JH, Chen L, Wang HR, Zhou D, Lin SC, Xu Q, Shen Y, Zhang J, Jurica MS, Benes CH, Deng X. Wang Y, et al. Among authors: li m, li l. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9. Cell Chem Biol. 2020. PMID: 32649904 Free article.
Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1.
Li M, Zhang CS, Feng JW, Wei X, Zhang C, Xie C, Wu Y, Hawley SA, Atrih A, Lamont DJ, Wang Z, Piao HL, Hardie DG, Lin SC. Li M, et al. Cell Res. 2021 Apr;31(4):478-481. doi: 10.1038/s41422-020-00456-8. Epub 2020 Dec 21. Cell Res. 2021. PMID: 33349646 Free PMC article. No abstract available.
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