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High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation.
Magis W, DeWitt MA, Wyman SK, Vu JT, Heo SJ, Shao SJ, Hennig F, Romero ZG, Campo-Fernandez B, Said S, McNeill MS, Rettig GR, Sun Y, Wang Y, Behlke MA, Kohn DB, Boffelli D, Walters MC, Corn JE, Martin DIK. Magis W, et al. iScience. 2022 May 10;25(6):104374. doi: 10.1016/j.isci.2022.104374. eCollection 2022 Jun 17. iScience. 2022. PMID: 35633935 Free PMC article.
Enhancers increase the probability but not the level of gene expression.
Walters MC, Fiering S, Eidemiller J, Magis W, Groudine M, Martin DI. Walters MC, et al. Among authors: magis w. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7125-9. doi: 10.1073/pnas.92.15.7125. Proc Natl Acad Sci U S A. 1995. PMID: 7624382 Free PMC article.
12 results