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Page 1
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. Kotschy A, et al. Among authors: szabo zb. Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19. Nature. 2016. PMID: 27760111
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
Szlávik Z, Ondi L, Csékei M, Paczal A, Szabó ZB, Radics G, Murray J, Davidson J, Chen I, Davis B, Hubbard RE, Pedder C, Dokurno P, Surgenor A, Smith J, Robertson A, LeToumelin-Braizat G, Cauquil N, Zarka M, Demarles D, Perron-Sierra F, Claperon A, Colland F, Geneste O, Kotschy A. Szlávik Z, et al. Among authors: szabo zb. J Med Chem. 2019 Aug 8;62(15):6913-6924. doi: 10.1021/acs.jmedchem.9b00134. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31339316
Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor.
Szlavik Z, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Murray J, Davidson J, Chen I, Dokurno P, Surgenor AE, Daniels ZM, Hubbard RE, Le Toumelin-Braizat G, Claperon A, Lysiak-Auvity G, Girard AM, Bruno A, Chanrion M, Colland F, Maragno AL, Demarles D, Geneste O, Kotschy A. Szlavik Z, et al. Among authors: szabo zb. J Med Chem. 2020 Nov 25;63(22):13762-13795. doi: 10.1021/acs.jmedchem.0c01234. Epub 2020 Nov 4. J Med Chem. 2020. PMID: 33146521
The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
Sipos S, Bálint B, Szabó ZB, Ondi L, Csékei M, Szlávik Z, Proszenyák Á, Murray JB, Davidson J, Chen I, Dokurno P, Surgenor AE, Pedder C, Hubbard RE, Maragno AL, Chanrion M, Colland F, Geneste O, Kotschy A. Sipos S, et al. Among authors: szabo zb. ACS Omega. 2021 Aug 18;6(34):22073-22102. doi: 10.1021/acsomega.1c02595. eCollection 2021 Aug 31. ACS Omega. 2021. PMID: 34497901 Free PMC article.
Structure-Activity Relationship of Azaindole-Based Glucokinase Activators.
Paczal A, Bálint B, Wéber C, Szabó ZB, Ondi L, Theret I, De Ceuninck F, Bernard C, Ktorza A, Perron-Sierra F, Kotschy A. Paczal A, et al. Among authors: szabo zb. J Med Chem. 2016 Jan 28;59(2):687-706. doi: 10.1021/acs.jmedchem.5b01594. Epub 2016 Jan 15. J Med Chem. 2016. PMID: 26685731
Interdisciplinary Round-Robin Test on Molecular Spectroscopy of the U(VI) Acetate System.
Müller K, Foerstendorf H, Steudtner R, Tsushima S, Kumke MU, Lefèvre G, Rothe J, Mason H, Szabó Z, Yang P, Adam CKR, André R, Brennenstuhl K, Chiorescu I, Cho HM, Creff G, Coppin F, Dardenne K, Den Auwer C, Drobot B, Eidner S, Hess NJ, Kaden P, Kremleva A, Kretzschmar J, Krüger S, Platts JA, Panak PJ, Polly R, Powell BA, Rabung T, Redon R, Reiller PE, Rösch N, Rossberg A, Scheinost AC, Schimmelpfennig B, Schreckenbach G, Skerencak-Frech A, Sladkov V, Solari PL, Wang Z, Washton NM, Zhang X. Müller K, et al. ACS Omega. 2019 May 3;4(5):8167-8177. doi: 10.1021/acsomega.9b00164. eCollection 2019 May 31. ACS Omega. 2019. PMID: 31459906 Free PMC article.
New nepenthone and thevinone derivatives.
Marton J, Simon C, Hosztafi S, Szabó Z, Márki A, Borsodi A, Makleit S. Marton J, et al. Bioorg Med Chem. 1997 Feb;5(2):369-82. doi: 10.1016/s0968-0896(96)00257-x. Bioorg Med Chem. 1997. PMID: 9061201
37 results