Young K - Search Results

1

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.

Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge JJ. Young K, et al. J Exp Med. 2016 Oct 17;213(11):2259-2267. doi: 10.1084/jem.20160168. Epub 2016 Oct 10. J Exp Med. 2016. PMID: 27811054 Free PMC article.

2

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.

George J, Uyar A, Young K, Kuffler L, Waldron-Francis K, Marquez E, Ucar D, Trowbridge JJ. George J, et al. Among authors: young k. Nat Commun. 2016 Jul 11;7:12166. doi: 10.1038/ncomms12166. Nat Commun. 2016. PMID: 27397025 Free PMC article.

3

Open chromatin profiling as a novel strategy for identifying cancer cell of origin.

Young K, Trowbridge JJ. Young K, et al. Mol Cell Oncol. 2016 Sep 30;3(6):e1236770. doi: 10.1080/23723556.2016.1236770. eCollection 2016. Mol Cell Oncol. 2016. PMID: 28090579 Free PMC article.

4

Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.

Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ. Loberg MA, et al. Among authors: young k. Leukemia. 2019 Jul;33(7):1635-1649. doi: 10.1038/s41375-018-0368-6. Epub 2019 Jan 28. Leukemia. 2019. PMID: 30692594 Free PMC article.

5

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.

Khokhar ES, Borikar S, Eudy E, Stearns T, Young K, Trowbridge JJ. Khokhar ES, et al. Among authors: young k. Exp Hematol. 2020 Feb;82:43-52.e4. doi: 10.1016/j.exphem.2020.01.014. Epub 2020 Feb 1. Exp Hematol. 2020. PMID: 32014431 Free PMC article.

6

Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias.

Young K, Loberg MA, Eudy E, Schwartz LS, Mujica KD, Trowbridge JJ. Young K, et al. Exp Hematol. 2020 Sep;89:61-67.e3. doi: 10.1016/j.exphem.2020.07.012. Epub 2020 Aug 6. Exp Hematol. 2020. PMID: 32768438 Free PMC article.

7

Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis.

SanMiguel JM, Young K, Trowbridge JJ. SanMiguel JM, et al. Among authors: young k. Exp Hematol. 2020 Nov;91:1-9. doi: 10.1016/j.exphem.2020.09.197. Epub 2020 Sep 28. Exp Hematol. 2020. PMID: 32991978 Free PMC article. Review.

8

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.

Young K, Eudy E, Bell R, Loberg MA, Stearns T, Sharma D, Velten L, Haas S, Filippi MD, Trowbridge JJ. Young K, et al. Cell Stem Cell. 2021 Aug 5;28(8):1473-1482.e7. doi: 10.1016/j.stem.2021.03.017. Epub 2021 Apr 12. Cell Stem Cell. 2021. PMID: 33848471 Free PMC article.

9

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis.

SanMiguel JM, Eudy E, Loberg MA, Young KA, Mistry JJ, Mujica KD, Schwartz LS, Stearns TM, Challen GA, Trowbridge JJ. SanMiguel JM, et al. Cancer Discov. 2022 Dec 2;12(12):2763-2773. doi: 10.1158/2159-8290.CD-22-0086. Cancer Discov. 2022. PMID: 36169447 Free PMC article.

10

Oncostatin M is a Master Regulator of an Inflammatory Network in Dnmt3a -Mutant Hematopoietic Stem Cells.

Schwartz LS, Young KA, Stearns TM, Boyer N, Mujica KD, Trowbridge JJ. Schwartz LS, et al. bioRxiv [Preprint]. 2023 Jul 12:2023.07.12.548764. doi: 10.1101/2023.07.12.548764. bioRxiv. 2023. PMID: 37502912 Free PMC article. Preprint.

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