Hadden MK - Search Results

1

A molecular dynamics approach to identify an oxysterol-based hedgehog pathway inhibitor.

Dash RC, Maschinot CR, Hadden MK. Dash RC, et al. Among authors: hadden mk. Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):168-177. doi: 10.1016/j.bbagen.2016.11.003. Epub 2016 Nov 5. Biochim Biophys Acta Gen Subj. 2017. PMID: 27825830

2

Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway.

DeBerardinis AM, Banerjee U, Miller M, Lemieux S, Hadden MK. DeBerardinis AM, et al. Among authors: hadden mk. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4859-63. doi: 10.1016/j.bmcl.2012.05.037. Epub 2012 May 23. Bioorg Med Chem Lett. 2012. PMID: 22687748

3

Hedgehog pathway inhibitors: a patent review (2009--present).

Hadden MK. Hadden MK. Expert Opin Ther Pat. 2013 Mar;23(3):345-61. doi: 10.1517/13543776.2013.757304. Epub 2013 Jan 8. Expert Opin Ther Pat. 2013. PMID: 23294277 Review.

4

Hedgehog pathway agonism: therapeutic potential and small-molecule development.

Hadden MK. Hadden MK. ChemMedChem. 2014 Jan;9(1):27-37. doi: 10.1002/cmdc.201300358. Epub 2013 Nov 7. ChemMedChem. 2014. PMID: 24203435 Review.

5

Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors.

Deberardinis AM, Madden DJ, Banerjee U, Sail V, Raccuia DS, De Carlo D, Lemieux SM, Meares A, Hadden MK. Deberardinis AM, et al. Among authors: hadden mk. J Med Chem. 2014 May 8;57(9):3724-36. doi: 10.1021/jm401812d. Epub 2014 Apr 28. J Med Chem. 2014. PMID: 24730984

6

Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.

Banerjee U, Hadden MK. Banerjee U, et al. Among authors: hadden mk. Expert Opin Drug Discov. 2014 Jul;9(7):751-71. doi: 10.1517/17460441.2014.920817. Epub 2014 May 22. Expert Opin Drug Discov. 2014. PMID: 24850423 Review.

7

Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway.

Corman A, DeBerardinis AM, Hadden MK. Corman A, et al. Among authors: hadden mk. ACS Med Chem Lett. 2012 Aug 28;3(10):828-33. doi: 10.1021/ml300192k. eCollection 2012 Oct 11. ACS Med Chem Lett. 2012. PMID: 24900386 Free PMC article.

8

Design, synthesis, and evaluation of hybrid vitamin D3 side chain analogues as hedgehog pathway inhibitors.

Banerjee U, DeBerardinis AM, Hadden MK. Banerjee U, et al. Among authors: hadden mk. Bioorg Med Chem. 2015 Feb 1;23(3):548-55. doi: 10.1016/j.bmc.2014.12.005. Epub 2014 Dec 10. Bioorg Med Chem. 2015. PMID: 25549899

9

Targeting GLI proteins in human cancer by small molecules (WO2014116651 A1): a patent evaluation.

Hadden MK. Hadden MK. Expert Opin Ther Pat. 2015 May;25(5):613-7. doi: 10.1517/13543776.2015.1019467. Epub 2015 Mar 15. Expert Opin Ther Pat. 2015. PMID: 25772316

10

Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.

Maschinot CA, Pace JR, Hadden MK. Maschinot CA, et al. Among authors: hadden mk. Curr Med Chem. 2015;22(35):4033-57. doi: 10.2174/0929867322666150827093904. Curr Med Chem. 2015. PMID: 26310919 Free PMC article. Review.

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