Trim PJ - Search Results

1

Slow, continuous enzyme replacement via spinal CSF in dogs with the paediatric-onset neurodegenerative disease, MPS IIIA.

King B, Marshall NR, Hassiotis S, Trim PJ, Tucker J, Hattersley K, Snel MF, Jolly RD, Hopwood JJ, Hemsley KM. King B, et al. Among authors: trim pj. J Inherit Metab Dis. 2017 May;40(3):443-453. doi: 10.1007/s10545-016-9994-1. Epub 2016 Nov 10. J Inherit Metab Dis. 2017. PMID: 27832416

2

A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA.

Trim PJ, Lau AA, Hopwood JJ, Snel MF. Trim PJ, et al. Rapid Commun Mass Spectrom. 2014 Apr 30;28(8):933-8. doi: 10.1002/rcm.6861. Rapid Commun Mass Spectrom. 2014. PMID: 24623698

3

Disease stage determines the efficacy of treatment of a paediatric neurodegenerative disease.

Hassiotis S, Beard H, Luck A, Trim PJ, King B, Snel MF, Hopwood JJ, Hemsley KM. Hassiotis S, et al. Among authors: trim pj. Eur J Neurosci. 2014 Jun;39(12):2139-50. doi: 10.1111/ejn.12557. Eur J Neurosci. 2014. PMID: 25068161

4

Delivery of therapeutic protein for prevention of neurodegenerative changes: comparison of different CSF-delivery methods.

Marshall NR, Hassiotis S, King B, Rozaklis T, Trim PJ, Duplock SK, Winner LK, Beard H, Snel MF, Jolly RD, Hopwood JJ, Hemsley KM. Marshall NR, et al. Among authors: trim pj. Exp Neurol. 2015 Jan;263:79-90. doi: 10.1016/j.expneurol.2014.09.008. Epub 2014 Sep 22. Exp Neurol. 2015. PMID: 25246230

5

Evaluation of enzyme dose and dose-frequency in ameliorating substrate accumulation in MPS IIIA Huntaway dog brain.

King B, Marshall N, Beard H, Hassiotis S, Trim PJ, Snel MF, Rozaklis T, Jolly RD, Hopwood JJ, Hemsley KM. King B, et al. Among authors: trim pj. J Inherit Metab Dis. 2015 Mar;38(2):341-50. doi: 10.1007/s10545-014-9790-8. Epub 2014 Nov 25. J Inherit Metab Dis. 2015. PMID: 25421091

6

Determination of the role of injection site on the efficacy of intra-CSF enzyme replacement therapy in MPS IIIA mice.

Beard H, Luck AJ, Hassiotis S, King B, Trim PJ, Snel MF, Hopwood JJ, Hemsley KM. Beard H, et al. Among authors: trim pj. Mol Genet Metab. 2015 May;115(1):33-40. doi: 10.1016/j.ymgme.2015.03.002. Epub 2015 Mar 12. Mol Genet Metab. 2015. PMID: 25795516

7

Butanolysis derivatization: improved sensitivity in LC-MS/MS quantitation of heparan sulfate in urine from mucopolysaccharidosis patients.

Trim PJ, Hopwood JJ, Snel MF. Trim PJ, et al. Anal Chem. 2015 Sep 15;87(18):9243-50. doi: 10.1021/acs.analchem.5b01743. Epub 2015 Aug 27. Anal Chem. 2015. PMID: 26301744

8

Low-dose, continual enzyme delivery ameliorates some aspects of established brain disease in a mouse model of a childhood-onset neurodegenerative disorder.

King B, Setford ML, Hassiotis S, Trim PJ, Duplock S, Tucker JN, Hattersley K, Snel MF, Hopwood JJ, Hemsley KM. King B, et al. Among authors: trim pj. Exp Neurol. 2016 Apr;278:11-21. doi: 10.1016/j.expneurol.2015.11.013. Epub 2015 Nov 26. Exp Neurol. 2016. PMID: 26626972

9

Low-dose, continuous enzyme replacement therapy ameliorates brain pathology in the neurodegenerative lysosomal disorder mucopolysaccharidosis type IIIA.

King B, Hassiotis S, Rozaklis T, Beard H, Trim PJ, Snel MF, Hopwood JJ, Hemsley KM. King B, et al. Among authors: trim pj. J Neurochem. 2016 May;137(3):409-22. doi: 10.1111/jnc.13533. Epub 2016 Feb 24. J Neurochem. 2016. PMID: 26762778 Free article.

10

Small molecule MALDI MS imaging: Current technologies and future challenges.

Trim PJ, Snel MF. Trim PJ, et al. Methods. 2016 Jul 15;104:127-41. doi: 10.1016/j.ymeth.2016.01.011. Epub 2016 Jan 22. Methods. 2016. PMID: 26804564 Review.

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