Fry AM - Search Results

1

Structure-guided design of purine-based probes for selective Nek2 inhibition.

Coxon CR, Wong C, Bayliss R, Boxall K, Carr KH, Fry AM, Hardcastle IR, Matheson CJ, Newell DR, Sivaprakasam M, Thomas H, Turner D, Yeoh S, Wang LZ, Griffin RJ, Golding BT, Cano C. Coxon CR, et al. Among authors: fry am. Oncotarget. 2017 Mar 21;8(12):19089-19124. doi: 10.18632/oncotarget.13249. Oncotarget. 2017. PMID: 27833088 Free PMC article.

2

The Nek2 protein kinase: a novel regulator of centrosome structure.

Fry AM. Fry AM. Oncogene. 2002 Sep 9;21(40):6184-94. doi: 10.1038/sj.onc.1205711. Oncogene. 2002. PMID: 12214248 Review.

3

The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer.

Hayward DG, Clarke RB, Faragher AJ, Pillai MR, Hagan IM, Fry AM. Hayward DG, et al. Among authors: fry am. Cancer Res. 2004 Oct 15;64(20):7370-6. doi: 10.1158/0008-5472.CAN-04-0960. Cancer Res. 2004. PMID: 15492258

4

Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.

Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM. Hames RS, et al. Among authors: fry am. Mol Biol Cell. 2005 Apr;16(4):1711-24. doi: 10.1091/mbc.e04-08-0688. Epub 2005 Jan 19. Mol Biol Cell. 2005. PMID: 15659651 Free PMC article.

5

Nek2 kinase in chromosome instability and cancer.

Hayward DG, Fry AM. Hayward DG, et al. Among authors: fry am. Cancer Lett. 2006 Jun 18;237(2):155-66. doi: 10.1016/j.canlet.2005.06.017. Epub 2005 Aug 3. Cancer Lett. 2006. PMID: 16084011 Review.

6

Insights into the conformational variability and regulation of human Nek2 kinase.

Westwood I, Cheary DM, Baxter JE, Richards MW, van Montfort RL, Fry AM, Bayliss R. Westwood I, et al. Among authors: fry am. J Mol Biol. 2009 Feb 20;386(2):476-85. doi: 10.1016/j.jmb.2008.12.033. Epub 2008 Dec 24. J Mol Biol. 2009. PMID: 19124027 Free PMC article.

7

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

Richards MW, O'Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R. Richards MW, et al. Among authors: fry am. Mol Cell. 2009 Nov 25;36(4):560-70. doi: 10.1016/j.molcel.2009.09.038. Mol Cell. 2009. PMID: 19941817 Free PMC article.

8

Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated nek2 kinase.

Hayward DG, Newbatt Y, Pickard L, Byrne E, Mao G, Burns S, Sahota NK, Workman P, Collins I, Aherne W, Fry AM. Hayward DG, et al. Among authors: fry am. J Biomol Screen. 2010 Sep;15(8):918-927. doi: 10.1177/1087057110376537. Epub 2010 Jul 27. J Biomol Screen. 2010. PMID: 20664067 Free PMC article.

9

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.

Zalli D, Bayliss R, Fry AM. Zalli D, et al. Among authors: fry am. Hum Mol Genet. 2012 Mar 1;21(5):1155-71. doi: 10.1093/hmg/ddr544. Epub 2011 Nov 21. Hum Mol Genet. 2012. PMID: 22106379 Free PMC article.

10

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.

Innocenti P, Cheung KM, Solanki S, Mas-Droux C, Rowan F, Yeoh S, Boxall K, Westlake M, Pickard L, Hardy T, Baxter JE, Aherne GW, Bayliss R, Fry AM, Hoelder S. Innocenti P, et al. Among authors: fry am. J Med Chem. 2012 Apr 12;55(7):3228-41. doi: 10.1021/jm201683b. Epub 2012 Mar 23. J Med Chem. 2012. PMID: 22404346 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

439 results

Search Page

Filters