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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Jin T, et al. Among authors: fitzgerald ka. Immunity. 2012 Apr 20;36(4):561-71. doi: 10.1016/j.immuni.2012.02.014. Epub 2012 Apr 5. Immunity. 2012. PMID: 22483801 Free PMC article.
Immunology. Select inflammasome assembly.
Caffrey DR, Fitzgerald KA. Caffrey DR, et al. Among authors: fitzgerald ka. Science. 2012 Apr 27;336(6080):420-1. doi: 10.1126/science.1222362. Science. 2012. PMID: 22539706 No abstract available.
A long noncoding RNA mediates both activation and repression of immune response genes.
Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA. Carpenter S, et al. Among authors: fitzgerald ka. Science. 2013 Aug 16;341(6147):789-92. doi: 10.1126/science.1240925. Epub 2013 Aug 1. Science. 2013. PMID: 23907535 Free PMC article.
Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.
Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. Shah S, et al. Among authors: fitzgerald ka. J Immunol. 2013 Oct 1;191(7):3514-8. doi: 10.4049/jimmunol.1301331. Epub 2013 Aug 30. J Immunol. 2013. PMID: 23997220 Free PMC article.
Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
Kailasan Vanaja S, Rathinam VA, Atianand MK, Kalantari P, Skehan B, Fitzgerald KA, Leong JM. Kailasan Vanaja S, et al. Among authors: fitzgerald ka. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7765-70. doi: 10.1073/pnas.1400075111. Epub 2014 May 14. Proc Natl Acad Sci U S A. 2014. PMID: 24828532 Free PMC article.
Identification of Aim2 as a sensor for DNA vaccines.
Suschak JJ, Wang S, Fitzgerald KA, Lu S. Suschak JJ, et al. Among authors: fitzgerald ka. J Immunol. 2015 Jan 15;194(2):630-6. doi: 10.4049/jimmunol.1402530. Epub 2014 Dec 8. J Immunol. 2015. PMID: 25488991 Free PMC article.
365 results