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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
Douthwaite J, Moisan J, Privezentzev C, Soskic B, Sabbah S, Cohen S, Collinson A, England E, Huntington C, Kemp B, Zhuang L, Hudak S, Rees DG, Goldberg D, Barton C, Chang L, Vainshtein I, Liang M, Iciek L, Ambery P, Peakman M, Vaughan TJ, Tree TI, Sansom DM, Bowen MA, Minter RR, Jermutus L. Douthwaite J, et al. Among authors: minter rr. J Immunol. 2017 Jan 1;198(1):528-537. doi: 10.4049/jimmunol.1600682. Epub 2016 Nov 23. J Immunol. 2017. PMID: 27881707
Probing a protein-protein interaction by in vitro evolution.
Thom G, Cockroft AC, Buchanan AG, Candotti CJ, Cohen ES, Lowne D, Monk P, Shorrock-Hart CP, Jermutus L, Minter RR. Thom G, et al. Among authors: minter rr. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7619-24. doi: 10.1073/pnas.0602341103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684878 Free PMC article.
Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis.
Minter RR, Cohen ES, Wang B, Liang M, Vainshtein I, Rees G, Eghobamien L, Harrison P, Sims DA, Matthews C, Wilkinson T, Monk P, Drinkwater C, Fabri L, Nash A, McCourt M, Jermutus L, Roskos L, Anderson IK, Sleeman MA. Minter RR, et al. Br J Pharmacol. 2013 Jan;168(1):200-11. doi: 10.1111/j.1476-5381.2012.02173.x. Br J Pharmacol. 2013. PMID: 22913645 Free PMC article.
Tailored amino acid diversity for the evolution of antibody affinity.
González-Muñoz A, Bokma E, O'Shea D, Minton K, Strain M, Vousden K, Rossant C, Jermutus L, Minter R. González-Muñoz A, et al. MAbs. 2012 Nov-Dec;4(6):664-72. doi: 10.4161/mabs.21728. Epub 2012 Aug 27. MAbs. 2012. PMID: 22926024 Free PMC article.
49 results