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Page 1
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.
Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, Hudson S, Doppalapudi VR, Stock J, Tchistiakova L, Bessire AJ, Clark T, Lucas J, Hosselet C, O'Donnell CJ, Subramanyam C. Tumey LN, et al. Among authors: leverett ca. ACS Med Chem Lett. 2016 Jun 22;7(11):977-982. doi: 10.1021/acsmedchemlett.6b00195. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882194 Free PMC article.
Synthetic approaches to the 2012 new drugs.
Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Sakya SM, Flick AC, O'Donnell CJ. Ding HX, et al. Among authors: leverett ca. Bioorg Med Chem. 2014 Apr 1;22(7):2005-32. doi: 10.1016/j.bmc.2014.02.017. Epub 2014 Feb 25. Bioorg Med Chem. 2014. PMID: 24629448 Review.
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ. Maderna A, et al. Among authors: leverett ca. J Med Chem. 2014 Dec 26;57(24):10527-43. doi: 10.1021/jm501649k. Epub 2014 Dec 9. J Med Chem. 2014. PMID: 25431858
Synthetic approaches to the 2013 new drugs.
Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, Flick AC, O'Donnell CJ. Ding HX, et al. Among authors: leverett ca. Bioorg Med Chem. 2015 May 1;23(9):1895-922. doi: 10.1016/j.bmc.2015.02.056. Epub 2015 Mar 6. Bioorg Med Chem. 2015. PMID: 25797159 Review.
Synthetic approaches to the 2014 new drugs.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: leverett ca. Bioorg Med Chem. 2016 May 1;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 9. Bioorg Med Chem. 2016. PMID: 27020685 Review.
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
Leverett CA, Sukuru SC, Vetelino BC, Musto S, Parris K, Pandit J, Loganzo F, Varghese AH, Bai G, Liu B, Liu D, Hudson S, Doppalapudi VR, Stock J, O'Donnell CJ, Subramanyam C. Leverett CA, et al. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. doi: 10.1021/acsmedchemlett.6b00274. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882198 Free PMC article.
Synthetic Approaches to the New Drugs Approved During 2015.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: leverett ca. J Med Chem. 2017 Aug 10;60(15):6480-6515. doi: 10.1021/acs.jmedchem.7b00010. Epub 2017 May 3. J Med Chem. 2017. PMID: 28421763 Review.
Correction to Synthetic Approaches to the New Drugs Approved During 2015.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: leverett ca. J Med Chem. 2017 Oct 26;60(20):8680. doi: 10.1021/acs.jmedchem.7b01452. Epub 2017 Oct 16. J Med Chem. 2017. PMID: 29035530 No abstract available.
Synthetic Approaches to New Drugs Approved During 2016.
Flick AC, Ding HX, Leverett CA, Fink SJ, O'Donnell CJ. Flick AC, et al. Among authors: leverett ca. J Med Chem. 2018 Aug 23;61(16):7004-7031. doi: 10.1021/acs.jmedchem.8b00260. Epub 2018 Apr 19. J Med Chem. 2018. PMID: 29620889 Review.
Synthetic Approaches to the New Drugs Approved During 2017.
Flick AC, Leverett CA, Ding HX, McInturff E, Fink SJ, Helal CJ, O'Donnell CJ. Flick AC, et al. Among authors: leverett ca. J Med Chem. 2019 Aug 22;62(16):7340-7382. doi: 10.1021/acs.jmedchem.9b00196. Epub 2019 Apr 15. J Med Chem. 2019. PMID: 30939001 Review.
28 results