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Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress.
van Ruissen MCE, van Kraaij SJW, Gal P, Bakker WA, Hijma HJ, Groeneveld GJ, de Kam ML, Burggraaf J, Moerland M. van Ruissen MCE, et al. Among authors: hijma hj. J Exp Pharmacol. 2024 Sep 17;16:285-294. doi: 10.2147/JEP.S473217. eCollection 2024. J Exp Pharmacol. 2024. PMID: 39308849 Free PMC article. Clinical Trial.
A phase I, randomized, double-blind, placebo-controlled, single- and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX-128, a highly selective Nav 1.8 inhibitor, in healthy adults.
Hijma HJ, van Brummelen EMJ, Siebenga PS, Groeneveld GJ. Hijma HJ, et al. Clin Transl Sci. 2022 Apr;15(4):981-993. doi: 10.1111/cts.13215. Epub 2021 Dec 27. Clin Transl Sci. 2022. PMID: 34958174 Free PMC article. Clinical Trial.
Challenging the challenge: A randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.
Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ. Hijma HJ, et al. Brain Behav Immun. 2020 Aug;88:515-528. doi: 10.1016/j.bbi.2020.04.033. Epub 2020 Apr 16. Brain Behav Immun. 2020. PMID: 32305572 Free article. Clinical Trial.