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Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Zhao R, et al. Among authors: lee mh, lee df. J Clin Invest. 2011 Mar;121(3):851-65. doi: 10.1172/JCI44111. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317535 Free PMC article.
Roles of COP9 signalosome in cancer.
Lee MH, Zhao R, Phan L, Yeung SC. Lee MH, et al. Cell Cycle. 2011 Sep 15;10(18):3057-66. doi: 10.4161/cc.10.18.17320. Epub 2011 Sep 15. Cell Cycle. 2011. PMID: 21876386 Free PMC article. Review.
Aurora B kinase phosphorylates and instigates degradation of p53.
Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Gully CP, et al. Among authors: lee mh. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):E1513-22. doi: 10.1073/pnas.1110287109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611192 Free PMC article.
FBXW7 is involved in Aurora B degradation.
Teng CL, Hsieh YC, Phan L, Shin J, Gully C, Velazquez-Torres G, Skerl S, Yeung SC, Hsu SL, Lee MH. Teng CL, et al. Among authors: lee mh. Cell Cycle. 2012 Nov 1;11(21):4059-68. doi: 10.4161/cc.22381. Epub 2012 Oct 24. Cell Cycle. 2012. PMID: 23095493 Free PMC article.
HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53.
Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. Xue Y, et al. Among authors: lee mh. Cell Cycle. 2012 Nov 15;11(22):4181-90. doi: 10.4161/cc.22413. Epub 2012 Oct 24. Cell Cycle. 2012. PMID: 23095642 Free PMC article.
CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6.
Chen B, Zhao R, Su CH, Linan M, Tseng C, Phan L, Fang L, Yang HY, Yang H, Wang W, Xu X, Jiang N, Cai S, Jin F, Yeung SC, Lee MH. Chen B, et al. Among authors: lee mh. Cell Cycle. 2012 Dec 15;11(24):4633-41. doi: 10.4161/cc.22887. Epub 2012 Nov 27. Cell Cycle. 2012. PMID: 23187808 Free PMC article.
5,379 results