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Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration.
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris MC, Clabbers A, Dong F, Shen J, Hackett SF, Touw DS, Bixby J, Zhong S, Benatuil L, Bose S, Grinnell C, Preston GM, Iyer R, Sadhukhan R, Marchie S, Overmeyer G, Ghayur T, van Riet DA, Tang S, Campochario PA, Gu J. Ding K, et al. Among authors: ghayur t. MAbs. 2017 Feb/Mar;9(2):269-284. doi: 10.1080/19420862.2016.1268305. MAbs. 2017. PMID: 27929753 Free PMC article.
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.
Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, Bose S, McCarthy D, Zhu RR, Santora L, Davis-Taber R, Kunes Y, Fung E, Schwartz A, Sakorafas P, Gu J, Tarcsa E, Murtaza A, Ghayur T. Wu C, et al. Among authors: ghayur t. Nat Biotechnol. 2007 Nov;25(11):1290-7. doi: 10.1038/nbt1345. Epub 2007 Oct 14. Nat Biotechnol. 2007. PMID: 17934452
Transmembrane TNF-dependent uptake of anti-TNF antibodies.
Deora A, Hegde S, Lee J, Choi CH, Chang Q, Lee C, Eaton L, Tang H, Wang D, Lee D, Michalak M, Tomlinson M, Tao Q, Gaur N, Harvey B, McLoughlin S, Labkovsky B, Ghayur T. Deora A, et al. Among authors: ghayur t. MAbs. 2017 May/Jun;9(4):680-695. doi: 10.1080/19420862.2017.1304869. Epub 2017 Mar 21. MAbs. 2017. PMID: 28323513 Free PMC article.
Recent advancements in DVD-Ig based therapeutic development.
Dong F, Ghayur T. Dong F, et al. Among authors: ghayur t. Drug Discov Today Technol. 2019 Dec;34:1-7. doi: 10.1016/j.ddtec.2020.10.002. Epub 2020 Nov 20. Drug Discov Today Technol. 2019. PMID: 33357765 Free article. Review. No abstract available.
53 results