Disney MD - Search Results

1

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Rzuczek SG, Colgan LA, Nakai Y, Cameron MD, Furling D, Yasuda R, Disney MD. Rzuczek SG, et al. Among authors: disney md. Nat Chem Biol. 2017 Feb;13(2):188-193. doi: 10.1038/nchembio.2251. Epub 2016 Dec 12. Nat Chem Biol. 2017. PMID: 27941760 Free PMC article.

2

Recent advances in developing small molecules targeting RNA.

Guan L, Disney MD. Guan L, et al. Among authors: disney md. ACS Chem Biol. 2012 Jan 20;7(1):73-86. doi: 10.1021/cb200447r. Epub 2012 Jan 12. ACS Chem Biol. 2012. PMID: 22185671 Review.

3

Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.

Kumar A, Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, Disney MD. Kumar A, et al. Among authors: disney md. ACS Chem Biol. 2012 Mar 16;7(3):496-505. doi: 10.1021/cb200413a. Epub 2012 Jan 17. ACS Chem Biol. 2012. PMID: 22252896 Free PMC article.

4

Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.

Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD. Parkesh R, et al. Among authors: disney md. J Am Chem Soc. 2012 Mar 14;134(10):4731-42. doi: 10.1021/ja210088v. Epub 2012 Mar 5. J Am Chem Soc. 2012. PMID: 22300544 Free PMC article.

5

Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.

Childs-Disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Childs-Disney JL, et al. Among authors: disney md. ACS Chem Biol. 2012 May 18;7(5):856-62. doi: 10.1021/cb200408a. Epub 2012 Mar 5. ACS Chem Biol. 2012. PMID: 22332923 Free PMC article.

6

A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.

Disney MD, Liu B, Yang WY, Sellier C, Tran T, Charlet-Berguerand N, Childs-Disney JL. Disney MD, et al. ACS Chem Biol. 2012 Oct 19;7(10):1711-8. doi: 10.1021/cb300135h. Epub 2012 Sep 4. ACS Chem Biol. 2012. PMID: 22948243 Free PMC article.

7

Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1.

Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD. Childs-Disney JL, et al. Among authors: disney md. ACS Chem Biol. 2012 Dec 21;7(12):1984-93. doi: 10.1021/cb3001606. Epub 2012 Nov 7. ACS Chem Biol. 2012. PMID: 23130637 Free PMC article.

8

Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing.

Velagapudi SP, Disney MD. Velagapudi SP, et al. Among authors: disney md. Bioorg Med Chem. 2013 Oct 15;21(20):6132-8. doi: 10.1016/j.bmc.2013.04.072. Epub 2013 May 7. Bioorg Med Chem. 2013. PMID: 23719281 Free PMC article.

9

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, Disney MD. Childs-Disney JL, et al. Among authors: disney md. Nat Commun. 2013;4:2044. doi: 10.1038/ncomms3044. Nat Commun. 2013. PMID: 23806903 Free PMC article.

10

Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions.

Guan L, Disney MD. Guan L, et al. Among authors: disney md. Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10010-3. doi: 10.1002/anie.201301639. Epub 2013 Aug 1. Angew Chem Int Ed Engl. 2013. PMID: 23913698 Free PMC article.

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