Nguyen AT - Search Results

1

Novel Irreversible Agonists Acting at the A₁ Adenosine Receptor.

Jörg M, Glukhova A, Abdul-Ridha A, Vecchio EA, Nguyen AT, Sexton PM, White PJ, May LT, Christopoulos A, Scammells PJ. Jörg M, et al. Among authors: nguyen at. J Med Chem. 2016 Dec 22;59(24):11182-11194. doi: 10.1021/acs.jmedchem.6b01561. Epub 2016 Dec 13. J Med Chem. 2016. PMID: 27958734

2

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.

Baltos JA, Paoletta S, Nguyen AT, Gregory KJ, Tosh DK, Christopoulos A, Jacobson KA, May LT. Baltos JA, et al. Among authors: nguyen at. Mol Pharmacol. 2016 Jul;90(1):12-22. doi: 10.1124/mol.116.103283. Epub 2016 May 2. Mol Pharmacol. 2016. PMID: 27136943 Free PMC article.

3

Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.

Nguyen AT, Vecchio EA, Thomas T, Nguyen TD, Aurelio L, Scammells PJ, White PJ, Sexton PM, Gregory KJ, May LT, Christopoulos A. Nguyen AT, et al. Among authors: nguyen td. Mol Pharmacol. 2016 Dec;90(6):715-725. doi: 10.1124/mol.116.105015. Epub 2016 Sep 28. Mol Pharmacol. 2016. PMID: 27683013

4

Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.

Nguyen AT, Baltos JA, Thomas T, Nguyen TD, Muñoz LL, Gregory KJ, White PJ, Sexton PM, Christopoulos A, May LT. Nguyen AT, et al. Among authors: nguyen td. Mol Pharmacol. 2016 Dec;90(6):703-714. doi: 10.1124/mol.116.105007. Epub 2016 Sep 28. Mol Pharmacol. 2016. PMID: 27683014

5

Structure of the Adenosine A₁ Receptor Reveals the Basis for Subtype Selectivity.

Glukhova A, Thal DM, Nguyen AT, Vecchio EA, Jörg M, Scammells PJ, May LT, Sexton PM, Christopoulos A. Glukhova A, et al. Among authors: nguyen at. Cell. 2017 Feb 23;168(5):867-877.e13. doi: 10.1016/j.cell.2017.01.042. Cell. 2017. PMID: 28235198 Free article.

6

α_1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes.

Sato M, Evans BA, Sandström AL, Chia LY, Mukaida S, Thai BS, Nguyen A, Lim L, Tan CYR, Baltos JA, White PJ, May LT, Hutchinson DS, Summers RJ, Bengtsson T. Sato M, et al. Biochem Pharmacol. 2018 Feb;148:27-40. doi: 10.1016/j.bcp.2017.11.016. Epub 2017 Nov 24. Biochem Pharmacol. 2018. PMID: 29175420 Free article.

7

A Structure-Activity Relationship Study of Bitopic N⁶-Substituted Adenosine Derivatives as Biased Adenosine A₁ Receptor Agonists.

Aurelio L, Baltos JA, Ford L, Nguyen ATN, Jörg M, Devine SM, Valant C, White PJ, Christopoulos A, May LT, Scammells PJ. Aurelio L, et al. J Med Chem. 2018 Mar 8;61(5):2087-2103. doi: 10.1021/acs.jmedchem.8b00047. Epub 2018 Feb 23. J Med Chem. 2018. PMID: 29446948

8

New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism.

Vecchio EA, Baltos JA, Nguyen ATN, Christopoulos A, White PJ, May LT. Vecchio EA, et al. Br J Pharmacol. 2018 Nov;175(21):4036-4046. doi: 10.1111/bph.14337. Epub 2018 Jun 21. Br J Pharmacol. 2018. PMID: 29679502 Free PMC article. Review.

9

Structure of the adenosine-bound human adenosine A₁ receptor-G_i complex.

Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A. Draper-Joyce CJ, et al. Nature. 2018 Jun;558(7711):559-563. doi: 10.1038/s41586-018-0236-6. Epub 2018 Jun 20. Nature. 2018. PMID: 29925945

10

Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor.

Miao Y, Bhattarai A, Nguyen ATN, Christopoulos A, May LT. Miao Y, et al. Sci Rep. 2018 Nov 15;8(1):16836. doi: 10.1038/s41598-018-35266-x. Sci Rep. 2018. PMID: 30442899 Free PMC article.

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