Gan J - Search Results

1

Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.

Gan J, Zhang H, Humphreys WG. Gan J, et al. Chem Res Toxicol. 2016 Dec 19;29(12):2040-2057. doi: 10.1021/acs.chemrestox.6b00274. Epub 2016 Dec 5. Chem Res Toxicol. 2016. PMID: 27989144 Review.

2

Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.

Gan J, Harper TW, Hsueh MM, Qu Q, Humphreys WG. Gan J, et al. Chem Res Toxicol. 2005 May;18(5):896-903. doi: 10.1021/tx0496791. Chem Res Toxicol. 2005. PMID: 15892584

3

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Gan J, Ruan Q, He B, Zhu M, Shyu WC, Humphreys WG. Gan J, et al. Chem Res Toxicol. 2009 Apr;22(4):690-8. doi: 10.1021/tx800368n. Chem Res Toxicol. 2009. PMID: 19253935

4

Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes.

Chen W, Caceres-Cortes J, Zhang H, Zhang D, Humphreys WG, Gan J. Chen W, et al. Among authors: gan j. Chem Res Toxicol. 2011 May 16;24(5):663-9. doi: 10.1021/tx100386z. Epub 2011 Apr 13. Chem Res Toxicol. 2011. PMID: 21417487

5

Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.

Zhang D, Flint O, Wang L, Gupta A, Westhouse RA, Zhao W, Raghavan N, Caceres-Cortes J, Marathe P, Shen G, Zhang Y, Allentoff A, Josephs J, Gan J, Borzilleri R, Humphreys WG. Zhang D, et al. Among authors: gan j. Chem Res Toxicol. 2012 Mar 19;25(3):556-71. doi: 10.1021/tx200524d. Epub 2012 Mar 2. Chem Res Toxicol. 2012. PMID: 22295996

6

High-resolution mass spectrometry-based background subtraction for identifying protein modifications in a complex biological system: detection of acetaminophen-bound microsomal proteins including argininosuccinate synthetase.

Zhang H, Gan J, Shu YZ, Humphreys WG. Zhang H, et al. Among authors: gan j. Chem Res Toxicol. 2015 Apr 20;28(4):775-81. doi: 10.1021/tx500526s. Epub 2015 Feb 16. Chem Res Toxicol. 2015. PMID: 25654186

7

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG. Zhang D, et al. Among authors: gan j. Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4. Drug Metab Dispos. 2013. PMID: 23382458

8

Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity.

Zhou L, Gan J, Yoshitsugu H, Gu X, Lutz JD, Masson E, Humphreys WG. Zhou L, et al. Among authors: gan j. CPT Pharmacometrics Syst Pharmacol. 2015 May;4(5):286-94. doi: 10.1002/psp4.35. Epub 2015 Apr 29. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26225254 Free PMC article.

9

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.

Shen H, Holenarsipur VK, Mariappan TT, Drexler DM, Cantone JL, Rajanna P, Singh Gautam S, Zhang Y, Gan J, Shipkova PA, Marathe P, Humphreys WG. Shen H, et al. Among authors: gan j. J Pharmacol Exp Ther. 2019 Jan;368(1):136-145. doi: 10.1124/jpet.118.252643. Epub 2018 Oct 25. J Pharmacol Exp Ther. 2019. PMID: 30361237 Clinical Trial.

10

CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).

Zhang D, Ly VT, Lago M, Tian Y, Gan J, Humphreys WG, Cömezoglu SN. Zhang D, et al. Among authors: gan j. Drug Metab Dispos. 2009 Apr;37(4):710-8. doi: 10.1124/dmd.108.024398. Epub 2009 Jan 21. Drug Metab Dispos. 2009. PMID: 19158314

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