Wilson M - Search Results

1

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.

Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB. Zheng H, et al. Among authors: wilson m. Nat Chem Biol. 2017 Feb;13(2):218-225. doi: 10.1038/nchembio.2259. Epub 2016 Dec 19. Nat Chem Biol. 2017. PMID: 27992879

2

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.

Larsen SD, Wilson MW, Abe A, Shu L, George CH, Kirchhoff P, Showalter HD, Xiang J, Keep RF, Shayman JA. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91. doi: 10.1194/jlr.M021261. Epub 2011 Nov 4. J Lipid Res. 2012. PMID: 22058426 Free PMC article.

3

Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.

Yestrepsky BD, Xu Y, Breen ME, Li X, Rajeswaran WG, Ryu JG, Sorenson RJ, Tsume Y, Wilson MW, Zhang W, Sun D, Sun H, Larsen SD. Yestrepsky BD, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1880-97. doi: 10.1016/j.bmc.2013.01.046. Epub 2013 Feb 1. Bioorg Med Chem. 2013. PMID: 23433668 Free PMC article.

4

Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.

Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Homan KT, et al. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov 12. Mol Pharmacol. 2014. PMID: 24220010 Free PMC article.

5

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.

Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. Báez-Santos YM, et al. Among authors: wilson mw. J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14. J Med Chem. 2014. PMID: 24568342 Free PMC article.

6

A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.

Deng X, Agnihothram S, Mielech AM, Nichols DB, Wilson MW, StJohn SE, Larsen SD, Mesecar AD, Lenschow DJ, Baric RS, Baker SC. Deng X, et al. Among authors: wilson mw. J Virol. 2014 Oct;88(20):11825-33. doi: 10.1128/JVI.01749-14. Epub 2014 Aug 6. J Virol. 2014. PMID: 25100850 Free PMC article.

7

Blockade of the renin-angiotensin system prevents acute and immunologically relevant colitis in murine models.

Okawada M, Wilson MW, Larsen SD, Lipka E, Hillfinger J, Teitelbaum DH. Okawada M, et al. Among authors: wilson mw. Pediatr Surg Int. 2016 Dec;32(12):1103-1114. doi: 10.1007/s00383-016-3965-3. Epub 2016 Sep 26. Pediatr Surg Int. 2016. PMID: 27670279

8

Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.

Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD. Hutchings KM, et al. Among authors: wilson mw. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. doi: 10.1016/j.bmcl.2017.02.070. Epub 2017 Mar 10. Bioorg Med Chem Lett. 2017. PMID: 28285914 Free PMC article.

9

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

Waldschmidt HV, Homan KT, Cato MC, Cruz-Rodríguez O, Cannavo A, Wilson MW, Song J, Cheung JY, Koch WJ, Tesmer JJ, Larsen SD. Waldschmidt HV, et al. J Med Chem. 2017 Apr 13;60(7):3052-3069. doi: 10.1021/acs.jmedchem.7b00112. Epub 2017 Mar 29. J Med Chem. 2017. PMID: 28323425 Free PMC article.

10

Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.

Gan X, Wilson MW, Beyett TS, Wen B, Sun D, Larsen SD, Tesmer JJG, Saltiel AR, Showalter HD. Gan X, et al. J Labelled Comp Radiopharm. 2019 May 15;62(5):202-208. doi: 10.1002/jlcr.3716. Epub 2019 Apr 3. J Labelled Comp Radiopharm. 2019. PMID: 30828860 Free PMC article.

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