Coleman JL - Search Results

1

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ. Ngo T, et al. Among authors: coleman jl. Nat Chem Biol. 2017 Feb;13(2):235-242. doi: 10.1038/nchembio.2266. Epub 2016 Dec 19. Nat Chem Biol. 2017. Retraction in: Nat Chem Biol. 2021 Apr;17(4):501. doi: 10.1038/s41589-021-00746-1 PMID: 27992882 Free PMC article. Retracted.

2

Using constitutive activity to define appropriate high-throughput screening assays for orphan g protein-coupled receptors.

Ngo T, Coleman JL, Smith NJ. Ngo T, et al. Among authors: coleman jl. Methods Mol Biol. 2015;1272:91-106. doi: 10.1007/978-1-4939-2336-6_7. Methods Mol Biol. 2015. PMID: 25563179

3

Identifying ligands at orphan GPCRs: current status using structure-based approaches.

Ngo T, Kufareva I, Coleman JLj, Graham RM, Abagyan R, Smith NJ. Ngo T, et al. Br J Pharmacol. 2016 Oct;173(20):2934-51. doi: 10.1111/bph.13452. Epub 2016 Mar 5. Br J Pharmacol. 2016. PMID: 26837045 Free PMC article. Review.

4

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.

Coleman JL, Ngo T, Schmidt J, Mrad N, Liew CK, Jones NM, Graham RM, Smith NJ. Coleman JL, et al. Sci Signal. 2016 Apr 12;9(423):ra36. doi: 10.1126/scisignal.aad1089. Sci Signal. 2016. PMID: 27072655

5

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era.

Coleman JL, Ngo T, Smith NJ. Coleman JL, et al. Cell Signal. 2017 May;33:1-9. doi: 10.1016/j.cellsig.2017.02.004. Epub 2017 Feb 8. Cell Signal. 2017. PMID: 28188824 Review.

6

Orphan receptor GPR37L1 remains unliganded.

Ngo T, Wilkins BP, So SS, Keov P, Chahal KK, Finch AM, Coleman JLJ, Kufareva I, Smith NJ. Ngo T, et al. Nat Chem Biol. 2021 Apr;17(4):383-386. doi: 10.1038/s41589-021-00748-z. Epub 2021 Mar 1. Nat Chem Biol. 2021. PMID: 33649602 Free PMC article. No abstract available.

7

Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JLJ, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ. Ngo T, et al. Nat Chem Biol. 2021 Apr;17(4):501. doi: 10.1038/s41589-021-00746-1. Nat Chem Biol. 2021. PMID: 33649604 Free PMC article. No abstract available.

8

GPCRs in context: sexual dimorphism in the cardiovascular system.

Mouat MA, Coleman JLJ, Smith NJ. Mouat MA, et al. Br J Pharmacol. 2018 Nov;175(21):4047-4059. doi: 10.1111/bph.14160. Epub 2018 Mar 25. Br J Pharmacol. 2018. PMID: 29451687 Free PMC article. Review.

9

Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control.

Coleman JLJ, Mouat MA, Wu J, Jancovski N, Bassi JK, Chan AY, Humphreys DT, Mrad N, Yu ZY, Ngo T, Iismaa S, Dos Remedios CG, Feneley MP, Allen AM, Graham RM, Smith NJ. Coleman JLJ, et al. Biol Sex Differ. 2018 Apr 6;9(1):14. doi: 10.1186/s13293-018-0173-y. Biol Sex Differ. 2018. PMID: 29625592 Free PMC article.

10

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases.

Coleman JLJ, Ngo T, Smythe RE, Cleave AJ, Jones NM, Graham RM, Smith NJ. Coleman JLJ, et al. Sci Rep. 2020 Nov 17;10(1):19995. doi: 10.1038/s41598-020-76384-9. Sci Rep. 2020. PMID: 33203955 Free PMC article.

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