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Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.
Gul SS, Hamilton AR, Munoz AR, Phupitakphol T, Liu W, Hyoju SK, Economopoulos KP, Morrison S, Hu D, Zhang W, Gharedaghi MH, Huo H, Hamarneh SR, Hodin RA. Gul SS, et al. Among authors: zhang w. Appl Physiol Nutr Metab. 2017 Jan;42(1):77-83. doi: 10.1139/apnm-2016-0346. Epub 2016 Nov 18. Appl Physiol Nutr Metab. 2017. PMID: 27997218 Free PMC article.
Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.
Liu W, Hu D, Huo H, Zhang W, Adiliaghdam F, Morrison S, Ramirez JM, Gul SS, Hamarneh SR, Hodin RA. Liu W, et al. Among authors: zhang w. J Am Coll Surg. 2016 Jun;222(6):1009-17. doi: 10.1016/j.jamcollsurg.2015.12.006. Epub 2015 Dec 18. J Am Coll Surg. 2016. PMID: 27106638 Free PMC article.
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