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52 results

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Page 1
Clinical pharmacodynamic/exposure characterisation of the multikinase inhibitor ilorasertib (ABT-348) in a phase 1 dose-escalation trial.
Maitland ML, Piha-Paul S, Falchook G, Kurzrock R, Nguyen L, Janisch L, Karovic S, McKee M, Hoening E, Wong S, Munasinghe W, Palma J, Donawho C, Lian GK, Ansell P, Ratain MJ, Hong D. Maitland ML, et al. Among authors: janisch l. Br J Cancer. 2018 Apr;118(8):1042-1050. doi: 10.1038/s41416-018-0020-2. Epub 2018 Mar 19. Br J Cancer. 2018. PMID: 29551775 Free PMC article. Clinical Trial.
A phase I study of continuous infusion cilengitide in patients with solid tumors.
O'Donnell PH, Undevia SD, Stadler WM, Karrison TM, Nicholas MK, Janisch L, Ratain MJ. O'Donnell PH, et al. Among authors: janisch l. Invest New Drugs. 2012 Apr;30(2):604-10. doi: 10.1007/s10637-010-9537-9. Epub 2010 Sep 14. Invest New Drugs. 2012. PMID: 20839028 Free PMC article. Clinical Trial.
Two drug interaction studies of sirolimus in combination with sorafenib or sunitinib in patients with advanced malignancies.
Gangadhar TC, Cohen EE, Wu K, Janisch L, Geary D, Kocherginsky M, House LK, Ramirez J, Undevia SD, Maitland ML, Fleming GF, Ratain MJ. Gangadhar TC, et al. Among authors: janisch l. Clin Cancer Res. 2011 Apr 1;17(7):1956-63. doi: 10.1158/1078-0432.CCR-10-2061. Epub 2011 Mar 29. Clin Cancer Res. 2011. PMID: 21447721 Free PMC article. Clinical Trial.
A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.
Sehdev A, Karrison T, Zha Y, Janisch L, Turcich M, Cohen EEW, Maitland M, Polite BN, Gajewski TF, Salgia R, Pinto N, Bissonnette MB, Fleming GF, Ratain MJ, Sharma MR. Sehdev A, et al. Among authors: janisch l. Cancer Chemother Pharmacol. 2018 Aug;82(2):309-317. doi: 10.1007/s00280-018-3619-3. Epub 2018 Jun 9. Cancer Chemother Pharmacol. 2018. PMID: 29948021 Free PMC article. Clinical Trial.
Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
Innocenti F, Schilsky RL, Ramírez J, Janisch L, Undevia S, House LK, Das S, Wu K, Turcich M, Marsh R, Karrison T, Maitland ML, Salgia R, Ratain MJ. Innocenti F, et al. Among authors: janisch l. J Clin Oncol. 2014 Aug 1;32(22):2328-34. doi: 10.1200/JCO.2014.55.2307. Epub 2014 Jun 23. J Clin Oncol. 2014. PMID: 24958824 Free PMC article. Clinical Trial.
Serum C-Telopeptide Collagen Crosslinks and Plasma Soluble VEGFR2 as Pharmacodynamic Biomarkers in a Trial of Sequentially Administered Sunitinib and Cilengitide.
O'Donnell PH, Karovic S, Karrison TG, Janisch L, Levine MR, Harris PJ, Polite BN, Cohen EE, Fleming GF, Ratain MJ, Maitland ML. O'Donnell PH, et al. Among authors: janisch l. Clin Cancer Res. 2015 Nov 15;21(22):5092-9. doi: 10.1158/1078-0432.CCR-15-0427. Epub 2015 Jul 21. Clin Cancer Res. 2015. PMID: 26199386 Free PMC article. Clinical Trial.
A phase I study of sirolimus and bevacizumab in patients with advanced malignancies.
Cohen EE, Sharma MR, Janisch L, Llobrera M, House L, Wu K, Ramirez J, Fleming GF, Stadler WM, Ratain MJ. Cohen EE, et al. Among authors: janisch l. Eur J Cancer. 2011 Jul;47(10):1484-9. doi: 10.1016/j.ejca.2011.02.017. Epub 2011 Mar 23. Eur J Cancer. 2011. PMID: 21439817 Free PMC article. Clinical Trial.
52 results