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The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis.
Fewings NL, Gatt PN, McKay FC, Parnell GP, Schibeci SD, Edwards J, Basuki MA, Goldinger A, Fabis-Pedrini MJ, Kermode AG, Manrique CP, McCauley JL, Nickles D, Baranzini SE, Burke T, Vucic S, Stewart GJ, Booth DR. Fewings NL, et al. Among authors: stewart gj. J Autoimmun. 2017 Mar;78:57-69. doi: 10.1016/j.jaut.2016.12.006. Epub 2017 Jan 4. J Autoimmun. 2017. PMID: 28063629
The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.
Parnell GP, Gatt PN, Krupa M, Nickles D, McKay FC, Schibeci SD, Batten M, Baranzini S, Henderson A, Barnett M, Slee M, Vucic S, Stewart GJ, Booth DR. Parnell GP, et al. Among authors: stewart gj. Clin Immunol. 2014 Mar;151(1):16-24. doi: 10.1016/j.clim.2014.01.003. Epub 2014 Jan 15. Clin Immunol. 2014. PMID: 24495857 Free article.
The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies.
McKay FC, Gatt PN, Fewings N, Parnell GP, Schibeci SD, Basuki MA, Powell JE, Goldinger A, Fabis-Pedrini MJ, Kermode AG, Burke T, Vucic S, Stewart GJ, Booth DR. McKay FC, et al. Among authors: stewart gj. Clin Immunol. 2016 Feb;163:96-107. doi: 10.1016/j.clim.2015.12.015. Epub 2016 Jan 4. Clin Immunol. 2016. PMID: 26762769
Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility.
Afrasiabi A, Parnell GP, Fewings N, Schibeci SD, Basuki MA, Chandramohan R, Zhou Y, Taylor B, Brown DA, Swaminathan S, McKay FC, Stewart GJ, Booth DR. Afrasiabi A, et al. Among authors: stewart gj. Genome Med. 2019 Apr 30;11(1):26. doi: 10.1186/s13073-019-0640-z. Genome Med. 2019. PMID: 31039804 Free PMC article.
Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions.
Law SPL, Gatt PN, Schibeci SD, McKay FC, Vucic S, Hart P, Byrne SN, Brown D, Stewart GJ, Liddle C, Parnell GP, Booth DR. Law SPL, et al. Among authors: stewart gj. Genes Immun. 2021 Aug;22(4):227-233. doi: 10.1038/s41435-021-00144-6. Epub 2021 Jun 23. Genes Immun. 2021. PMID: 34163021 Free PMC article.
306 results