Benek O - Search Results

1

6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation.

Benek O, Hroch L, Aitken L, Dolezal R, Guest P, Benkova M, Soukup O, Musil K, Kuca K, Smith TK, Gunn-Moore F, Musilek K. Benek O, et al. Med Chem. 2017 Jan 9. Online ahead of print. Med Chem. 2017. PMID: 28067167

2

[Mitochondrial enzyme ABAD and its role in the development and treatment of Alzheimer's disease].

Benek O, Musílek K, Kuca K. Benek O, et al. Ceska Slov Farm. 2012 Aug;61(4):144-9. Ceska Slov Farm. 2012. PMID: 23251955 Review. Czech.

3

[Tacrine and its derivatives in the therapy of Alzheimers disease].

Korábečný J, Spilovská K, Benek O, Musílek K, Soukup O, Kuča K. Korábečný J, et al. Among authors: benek o. Ceska Slov Farm. 2012 Oct;61(5):210-21. Ceska Slov Farm. 2012. PMID: 23256654 Review. Czech.

4

Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51.

Benek O, Musilek K, Horova A, Dohnal V, Dolezal R, Kuca K. Benek O, et al. Med Chem. 2014;11(1):21-9. doi: 10.2174/1573406410666140428153110. Med Chem. 2014. PMID: 24773345

5

Benzothiazoles - scaffold of interest for CNS targeted drugs.

Hroch L, Aitken L, Benek O, Dolezal M, Kuca K, Gunn-Moore F, Musilek K. Hroch L, et al. Among authors: benek o. Curr Med Chem. 2015;22(6):730-47. doi: 10.2174/0929867322666141212120631. Curr Med Chem. 2015. PMID: 25515509 Review.

6

A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease.

Benek O, Aitken L, Hroch L, Kuca K, Gunn-Moore F, Musilek K. Benek O, et al. Curr Med Chem. 2015 Feb 26;22(9):1056 - 1085. doi: 10.2174/0929867322666150114163051. Curr Med Chem. 2015. PMID: 25620098

7

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, Hrabinova M, Jun D, Kuca K, Zala D, Ramsay RR, Marco-Contelles J, Musilek K. Benek O, et al. ChemMedChem. 2016 Jun 20;11(12):1264-9. doi: 10.1002/cmdc.201500383. Epub 2015 Oct 2. ChemMedChem. 2016. PMID: 26427608

8

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.

Hroch L, Benek O, Guest P, Aitken L, Soukup O, Janockova J, Musil K, Dohnal V, Dolezal R, Kuca K, Smith TK, Gunn-Moore F, Musilek K. Hroch L, et al. Among authors: benek o. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3675-8. doi: 10.1016/j.bmcl.2016.05.087. Epub 2016 May 30. Bioorg Med Chem Lett. 2016. PMID: 27287370

9

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.

Hroch L, Guest P, Benek O, Soukup O, Janockova J, Dolezal R, Kuca K, Aitken L, Smith TK, Gunn-Moore F, Zala D, Ramsay RR, Musilek K. Hroch L, et al. Among authors: benek o. Bioorg Med Chem. 2017 Feb 1;25(3):1143-1152. doi: 10.1016/j.bmc.2016.12.029. Epub 2016 Dec 27. Bioorg Med Chem. 2017. PMID: 28082069

10

Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro.

Honegr J, Malinak D, Dolezal R, Soukup O, Benkova M, Hroch L, Benek O, Janockova J, Kuca K, Prymula R. Honegr J, et al. Among authors: benek o. Eur J Med Chem. 2018 Feb 25;146:38-46. doi: 10.1016/j.ejmech.2017.12.074. Epub 2018 Jan 11. Eur J Med Chem. 2018. PMID: 29407964

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