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Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response.
van Bergen CA, van Luxemburg-Heijs SA, de Wreede LC, Eefting M, von dem Borne PA, van Balen P, Heemskerk MH, Mulder A, Claas FH, Navarrete MA, Honders WM, Rutten CE, Veelken H, Jedema I, Halkes CJ, Griffioen M, Falkenburg JH. van Bergen CA, et al. Among authors: van luxemburg heijs sa, van balen p. J Clin Invest. 2017 Feb 1;127(2):517-529. doi: 10.1172/JCI86175. Epub 2017 Jan 9. J Clin Invest. 2017. PMID: 28067665 Free PMC article.
Alloreactive T Cell Receptor Diversity against Structurally Similar or Dissimilar HLA-DP Antigens Assessed by Deep Sequencing.
Arrieta-Bolaños E, Crivello P, Metzing M, Meurer T, Ahci M, Rytlewski J, Vignali M, Yusko E, van Balen P, Horn PA, Falkenburg JHF, Fleischhauer K. Arrieta-Bolaños E, et al. Among authors: van balen p. Front Immunol. 2018 Feb 19;9:280. doi: 10.3389/fimmu.2018.00280. eCollection 2018. Front Immunol. 2018. PMID: 29520276 Free PMC article.
Tissue Damage Caused by Myeloablative, but Not Non-Myeloablative, Conditioning before Allogeneic Stem Cell Transplantation Results in Dermal Macrophage Recruitment without Active T-Cell Interaction.
van Balen P, van der Zouwen B, Kruisselbrink AB, Eefting M, Szuhai K, Jordanova ES, Falkenburg JHF, Jedema I. van Balen P, et al. Among authors: van der zouwen b. Front Immunol. 2018 Feb 27;9:331. doi: 10.3389/fimmu.2018.00331. eCollection 2018. Front Immunol. 2018. PMID: 29535719 Free PMC article. Clinical Trial.
The allogeneic HLA-DP-restricted T-cell repertoire provoked by allogeneic dendritic cells contains T cells that show restricted recognition of hematopoietic cells including primary malignant cells.
Laghmouchi A, Hoogstraten C, van Balen P, Falkenburg JHF, Jedema I. Laghmouchi A, et al. Among authors: van balen p. Haematologica. 2019 Jan;104(1):197-206. doi: 10.3324/haematol.2018.193680. Epub 2018 Sep 20. Haematologica. 2019. PMID: 30237261 Free PMC article.
CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II.
van Balen P, van Bergen CAM, van Luxemburg-Heijs SAP, de Klerk W, van Egmond EHM, Veld SAJ, Halkes CJM, Zwaginga JJ, Griffioen M, Jedema I, Falkenburg JHF. van Balen P, et al. Among authors: van bergen cam, van egmond ehm, van luxemburg heijs sap. Front Immunol. 2018 Dec 18;9:3016. doi: 10.3389/fimmu.2018.03016. eCollection 2018. Front Immunol. 2018. PMID: 30619360 Free PMC article.
Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation-a phase I/II study.
Roex MCJ, van Balen P, Germeroth L, Hageman L, van Egmond E, Veld SAJ, Hoogstraten C, van Liempt E, Zwaginga JJ, de Wreede LC, Meij P, Vossen ACTM, Danhof S, Einsele H, Schaafsma MR, Veelken H, Halkes CJM, Jedema I, Falkenburg JHF. Roex MCJ, et al. Among authors: van egmond e, van liempt e, van balen p. Leukemia. 2020 Mar;34(3):831-844. doi: 10.1038/s41375-019-0600-z. Epub 2019 Oct 17. Leukemia. 2020. PMID: 31624377 Clinical Trial.
Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies.
van Balen P, Kester MGD, de Klerk W, Crivello P, Arrieta-Bolaños E, de Ru AH, Jedema I, Mohammed Y, Heemskerk MHM, Fleischhauer K, van Veelen PA, Falkenburg JHF. van Balen P, et al. Among authors: van veelen pa. J Immunol. 2020 Jun 15;204(12):3273-3282. doi: 10.4049/jimmunol.2000192. Epub 2020 Apr 29. J Immunol. 2020. PMID: 32350084
HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study.
van Balen P, Jedema I, van Loenen MM, de Boer R, van Egmond HM, Hagedoorn RS, Hoogstaten C, Veld SAJ, Hageman L, van Liempt PAG, Zwaginga JJ, Meij P, Veelken H, Falkenburg JHF, Heemskerk MHM. van Balen P, et al. Among authors: van egmond hm, van liempt pag, van loenen mm. Front Immunol. 2020 Aug 20;11:1804. doi: 10.3389/fimmu.2020.01804. eCollection 2020. Front Immunol. 2020. PMID: 32973756 Free PMC article. Clinical Trial.
38 results