Castets P - Search Results

1

Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.

Brockhoff M, Rion N, Chojnowska K, Wiktorowicz T, Eickhorst C, Erne B, Frank S, Angelini C, Furling D, Rüegg MA, Sinnreich M, Castets P. Brockhoff M, et al. Among authors: castets p. J Clin Invest. 2017 Feb 1;127(2):549-563. doi: 10.1172/JCI89616. Epub 2017 Jan 9. J Clin Invest. 2017. PMID: 28067669 Free PMC article.

2

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN, Rüegg MA. Bentzinger CF, et al. Among authors: castets p. Skelet Muscle. 2013 Mar 6;3(1):6. doi: 10.1186/2044-5040-3-6. Skelet Muscle. 2013. PMID: 23497627 Free PMC article.

3

Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.

Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M, Rüegg MA. Castets P, et al. Cell Metab. 2013 May 7;17(5):731-44. doi: 10.1016/j.cmet.2013.03.015. Epub 2013 Apr 18. Cell Metab. 2013. PMID: 23602450 Free article.

4

MTORC1 determines autophagy through ULK1 regulation in skeletal muscle.

Castets P, Rüegg MA. Castets P, et al. Autophagy. 2013 Sep;9(9):1435-7. doi: 10.4161/auto.25722. Epub 2013 Jul 23. Autophagy. 2013. PMID: 23896646 Free article.

5

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.

Guridi M, Tintignac LA, Lin S, Kupr B, Castets P, Rüegg MA. Guridi M, et al. Among authors: castets p. Sci Signal. 2015 Nov 10;8(402):ra113. doi: 10.1126/scisignal.aab3715. Sci Signal. 2015. PMID: 26554817

6

"Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders.

Castets P, Frank S, Sinnreich M, Rüegg MA. Castets P, et al. J Neuromuscul Dis. 2016 May 27;3(2):127-155. doi: 10.3233/JND-160153. J Neuromuscul Dis. 2016. PMID: 27854220 Free PMC article. Review.

7

mTOR controls embryonic and adult myogenesis via mTORC1.

Rion N, Castets P, Lin S, Enderle L, Reinhard JR, Eickhorst C, Rüegg MA. Rion N, et al. Among authors: castets p. Development. 2019 Apr 8;146(7):dev172460. doi: 10.1242/dev.172460. Development. 2019. PMID: 30872276

8

mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.

Castets P, Rion N, Théodore M, Falcetta D, Lin S, Reischl M, Wild F, Guérard L, Eickhorst C, Brockhoff M, Guridi M, Ibebunjo C, Cruz J, Sinnreich M, Rudolf R, Glass DJ, Rüegg MA. Castets P, et al. Nat Commun. 2019 Jul 18;10(1):3187. doi: 10.1038/s41467-019-11227-4. Nat Commun. 2019. PMID: 31320633 Free PMC article.

9

mTORC2 affects the maintenance of the muscle stem cell pool.

Rion N, Castets P, Lin S, Enderle L, Reinhard JR, Rüegg MA. Rion N, et al. Among authors: castets p. Skelet Muscle. 2019 Dec 2;9(1):30. doi: 10.1186/s13395-019-0217-y. Skelet Muscle. 2019. PMID: 31791403 Free PMC article.

10

The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?

Castets P, Ham DJ, Rüegg MA. Castets P, et al. Front Mol Neurosci. 2020 Aug 28;13:162. doi: 10.3389/fnmol.2020.00162. eCollection 2020. Front Mol Neurosci. 2020. PMID: 32982690 Free PMC article. Review.

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