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Page 1
K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.
Hao Z, Sheng Y, Duncan GS, Li WY, Dominguez C, Sylvester J, Su YW, Lin GH, Snow BE, Brenner D, You-Ten A, Haight J, Inoue S, Wakeham A, Elford A, Hamilton S, Liang Y, Zúñiga-Pflücker JC, He HH, Ohashi PS, Mak TW. Hao Z, et al. Among authors: sheng y. Nat Commun. 2017 Jan 13;8:14003. doi: 10.1038/ncomms14003. Nat Commun. 2017. PMID: 28084302 Free PMC article.
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. Hao Z, et al. Among authors: sheng y. J Exp Med. 2012 Jan 16;209(1):173-86. doi: 10.1084/jem.20111363. Epub 2012 Jan 2. J Exp Med. 2012. PMID: 22213803 Free PMC article.
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Dominguez-Brauer C, et al. Among authors: sheng y. Cell Stem Cell. 2016 Aug 4;19(2):205-216. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12. Cell Stem Cell. 2016. PMID: 27184401 Free PMC article.
E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.
Dominguez-Brauer C, Khatun R, Elia AJ, Thu KL, Ramachandran P, Baniasadi SP, Hao Z, Jones LD, Haight J, Sheng Y, Mak TW. Dominguez-Brauer C, et al. Among authors: sheng y. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1148-E1157. doi: 10.1073/pnas.1621355114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137882 Free PMC article.
Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.
Hao Z, Cairns RA, Inoue S, Li WY, Sheng Y, Lemonnier F, Wakeham A, Snow BE, Dominguez-Brauer C, Ye J, Larsen DM, Straley KS, Tobin ER, Narayanaswamy R, Gaulard P, Mak TW. Hao Z, et al. Among authors: sheng y. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1387-92. doi: 10.1073/pnas.1525354113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787889 Free PMC article.
Molecular basis of Pirh2-mediated p53 ubiquitylation.
Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH. Sheng Y, et al. Nat Struct Mol Biol. 2008 Dec;15(12):1334-42. doi: 10.1038/nsmb.1521. Epub 2008 Nov 30. Nat Struct Mol Biol. 2008. PMID: 19043414 Free PMC article.
The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.
Bohgaki M, Hakem A, Halaby MJ, Bohgaki T, Li Q, Bissey PA, Shloush J, Kislinger T, Sanchez O, Sheng Y, Hakem R. Bohgaki M, et al. Among authors: sheng y. Cell Death Differ. 2013 Jun;20(6):812-22. doi: 10.1038/cdd.2013.7. Epub 2013 Mar 1. Cell Death Differ. 2013. PMID: 23449389 Free PMC article.
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SS. Zhang W, et al. Among authors: sheng y. Mol Cell. 2016 Apr 7;62(1):121-36. doi: 10.1016/j.molcel.2016.02.005. Epub 2016 Mar 3. Mol Cell. 2016. PMID: 26949039 Free PMC article.
A site-directed mutagenesis study of the MdmX RING domain.
Egorova O, Mis M, Sheng Y. Egorova O, et al. Among authors: sheng y. Biochem Biophys Res Commun. 2014 May 16;447(4):696-701. doi: 10.1016/j.bbrc.2014.04.065. Epub 2014 Apr 19. Biochem Biophys Res Commun. 2014. PMID: 24755078
3,317 results