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The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. Lin A, et al. Among authors: yao j. Nat Cell Biol. 2017 Mar;19(3):238-251. doi: 10.1038/ncb3473. Epub 2017 Feb 20. Nat Cell Biol. 2017. PMID: 28218907 Free PMC article.
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. Wang S, et al. Among authors: yao j. J Clin Invest. 2017 Dec 1;127(12):4498-4515. doi: 10.1172/JCI91553. Epub 2017 Nov 13. J Clin Invest. 2017. PMID: 29130936 Free PMC article.
LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.
Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L. Hu Q, et al. Among authors: yao j. Cell Res. 2019 Apr;29(4):286-304. doi: 10.1038/s41422-018-0134-3. Epub 2019 Jan 10. Cell Res. 2019. PMID: 30631154 Free PMC article.
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Hu Q, et al. Among authors: yao j. Nat Immunol. 2019 Jul;20(7):835-851. doi: 10.1038/s41590-019-0400-7. Epub 2019 Jun 3. Nat Immunol. 2019. PMID: 31160797 Free PMC article.
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. Xu J, et al. Among authors: yao j. Cancer Cell. 2015 Feb 9;27(2):177-92. doi: 10.1016/j.ccell.2014.11.025. Cancer Cell. 2015. PMID: 25670079 Free PMC article.
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Li CW, et al. Among authors: yao j. Nat Commun. 2016 Aug 30;7:12632. doi: 10.1038/ncomms12632. Nat Commun. 2016. PMID: 27572267 Free PMC article.
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