Rademann J - Search Results

1

Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.

Jaegle M, Wong EL, Tauber C, Nawrotzky E, Arkona C, Rademann J. Jaegle M, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7358-7378. doi: 10.1002/anie.201610372. Epub 2017 May 31. Angew Chem Int Ed Engl. 2017. PMID: 28117936 Free PMC article. Review.

2

Organic protein chemistry: drug discovery through the chemical modification of proteins.

Rademann J. Rademann J. Angew Chem Int Ed Engl. 2004 Sep 6;43(35):4554-6. doi: 10.1002/anie.200460075. Angew Chem Int Ed Engl. 2004. PMID: 15317010 No abstract available.

3

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.

Schmidt MF, Isidro-Llobet A, Lisurek M, El-Dahshan A, Tan J, Hilgenfeld R, Rademann J. Schmidt MF, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2008;47(17):3275-8. doi: 10.1002/anie.200704594. Angew Chem Int Ed Engl. 2008. PMID: 18348134 Free PMC article.

4

Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics.

Ahsanullah; Schmieder P, Kühne R, Rademann J. Ahsanullah, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2009;48(27):5042-5. doi: 10.1002/anie.200806390. Angew Chem Int Ed Engl. 2009. PMID: 19472239

5

Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.

Schmidt MF, El-Dahshan A, Keller S, Rademann J. Schmidt MF, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2009;48(34):6346-9. doi: 10.1002/anie.200901647. Angew Chem Int Ed Engl. 2009. PMID: 19630042 No abstract available.

6

Dynamic template-assisted strategies in fragment-based drug discovery.

Schmidt MF, Rademann J. Schmidt MF, et al. Among authors: rademann j. Trends Biotechnol. 2009 Sep;27(9):512-21. doi: 10.1016/j.tibtech.2009.06.001. Epub 2009 Aug 11. Trends Biotechnol. 2009. PMID: 19679363 Free PMC article. Review.

7

Cyclative cleavage through dipolar cycloaddition: polymer-bound azidopeptidylphosphoranes deliver locked cis-triazolylcyclopeptides as privileged protein binders.

Ahsanullah, Rademann J. Ahsanullah, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2010 Jul 19;49(31):5378-82. doi: 10.1002/anie.200904980. Angew Chem Int Ed Engl. 2010. PMID: 20583012 No abstract available.

8

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G. Basters A, et al. Among authors: rademann j. BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56. BMC Biotechnol. 2012. PMID: 22916876 Free PMC article.

9

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

Arkona C, Rademann J. Arkona C, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8210-2. doi: 10.1002/anie.201303544. Epub 2013 Jun 21. Angew Chem Int Ed Engl. 2013. PMID: 23794491 No abstract available.

10

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation.

Preidl JJ, Gnanapragassam VS, Lisurek M, Saupe J, Horstkorte R, Rademann J. Preidl JJ, et al. Among authors: rademann j. Angew Chem Int Ed Engl. 2014 May 26;53(22):5700-5. doi: 10.1002/anie.201400394. Epub 2014 Apr 15. Angew Chem Int Ed Engl. 2014. PMID: 24737687

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