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Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease.
Cisbani G, Drouin-Ouellet J, Gibrat C, Saint-Pierre M, Lagacé M, Badrinarayanan S, Lavallée-Bourget MH, Charest J, Chabrat A, Boivin L, Lebel M, Bousquet M, Lévesque M, Cicchetti F. Cisbani G, et al. Among authors: levesque m. Neurobiol Dis. 2015 Oct;82:430-444. doi: 10.1016/j.nbd.2015.07.012. Epub 2015 Jul 29. Neurobiol Dis. 2015. PMID: 26232588
Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.
Doucet-Beaupré H, Gilbert C, Profes MS, Chabrat A, Pacelli C, Giguère N, Rioux V, Charest J, Deng Q, Laguna A, Ericson J, Perlmann T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Lévesque M. Doucet-Beaupré H, et al. Among authors: levesque m. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96. doi: 10.1073/pnas.1520387113. Epub 2016 Jul 12. Proc Natl Acad Sci U S A. 2016. PMID: 27407143 Free PMC article.
Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation.
Chabrat A, Brisson G, Doucet-Beaupré H, Salesse C, Schaan Profes M, Dovonou A, Akitegetse C, Charest J, Lemstra S, Côté D, Pasterkamp RJ, Abrudan MI, Metzakopian E, Ang SL, Lévesque M. Chabrat A, et al. Among authors: levesque m. Nat Commun. 2017 Oct 16;8(1):933. doi: 10.1038/s41467-017-01042-0. Nat Commun. 2017. PMID: 29038581 Free PMC article.
925 results