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Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.
Tian C, Zhang Y, Tong Y, Kock KH, Sim DY, Liu F, Dong J, Jing Z, Wang W, Gao J, Tan LM, Han KY, Tomofuji Y, Nakano M, Buyamin EV, Sonthalia R, Ando Y, Hatano H, Sonehara K; Asian Immune Diversity Atlas Network; Jin X, Loh M, Chambers J, Hon CC, Choi M, Park JE, Ishigaki K, Okamura T, Fujio K, Okada Y, Park WY, Shin JW, Roca X, Prabhakar S, Liu B. Tian C, et al. Nat Genet. 2024 Dec;56(12):2739-2752. doi: 10.1038/s41588-024-02019-8. Epub 2024 Dec 3. Nat Genet. 2024. PMID: 39627432 Free PMC article.
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.
Tomofuji Y, Edahiro R, Sonehara K, Shirai Y, Kock KH, Wang QS, Namba S, Moody J, Ando Y, Suzuki A, Yata T, Ogawa K, Naito T, Namkoong H, Xuan Lin QX, Buyamin EV, Tan LM, Sonthalia R, Han KY, Tanaka H, Lee H; Asian Immune Diversity Atlas (AIDA) Network; Japan COVID-19 Task Force; Biobank Japan Project; Okuno T, Liu B, Matsuda K, Fukunaga K, Mochizuki H, Park WY, Yamamoto K, Hon CC, Shin JW, Prabhakar S, Kumanogoh A, Okada Y. Tomofuji Y, et al. Cell Genom. 2024 Aug 14;4(8):100625. doi: 10.1016/j.xgen.2024.100625. Epub 2024 Jul 30. Cell Genom. 2024. PMID: 39084228 Free PMC article.
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis.
Yamazaki T, Kouno T, Hsu CL, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS Jr, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Schnabl B; AlcHepNet Investigators. Yamazaki T, et al. Among authors: kouno t. Hepatology. 2024 Aug 1;80(2):403-417. doi: 10.1097/HEP.0000000000000777. Epub 2024 Feb 20. Hepatology. 2024. PMID: 38377466
Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity.
Mitsui Y, Suzuki T, Kuniyoshi K, Inamo J, Yamaguchi K, Komuro M, Watanabe J, Edamoto M, Li S, Kouno T, Oba S, Hosoya T, Masuhiro K, Naito Y, Koyama S, Sakaguchi N, Standley DM, Shin JW, Akira S, Yasuda S, Miyazaki Y, Kochi Y, Kumanogoh A, Okamoto T, Satoh T. Mitsui Y, et al. Among authors: kouno t. Immunity. 2023 Aug 8;56(8):1939-1954.e12. doi: 10.1016/j.immuni.2023.06.013. Epub 2023 Jul 12. Immunity. 2023. PMID: 37442134 Free article.
Single-Cell RNA-Seq Reveals LRRC75A-Expressing Cell Population Involved in VEGF Secretion of Multipotent Mesenchymal Stromal/Stem Cells Under Ischemia.
Miura T, Kouno T, Takano M, Kuroda T, Yamamoto Y, Kusakawa S, Morioka MS, Sugawara T, Hirai T, Yasuda S, Sawada R, Matsuyama S, Kawaji H, Kasukawa T, Itoh M, Matsuyama A, Shin JW, Umezawa A, Kawai J, Sato Y. Miura T, et al. Among authors: kouno t. Stem Cells Transl Med. 2023 Jun 15;12(6):379-390. doi: 10.1093/stcltm/szad029. Stem Cells Transl Med. 2023. PMID: 37263619 Free PMC article.
Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice.
Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, Hartmann P, Cabré N, Llorente C, Galbert C, Emond P, Sokol H, James M, Chao CC, Gao JR, Perreault M, Hava DL, Schnabl B. Kouno T, et al. Alcohol Clin Exp Res (Hoboken). 2023 May;47(5):856-867. doi: 10.1111/acer.15048. Epub 2023 Mar 19. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 36871955 Free PMC article.
IgY antibodies against cytolysin reduce ethanol-induced liver disease in mice.
Cabré N, Hartmann P, Llorente C, Kouno T, Wang Y, Zeng S, Kim HY, Zhang X, Kisseleva T, Iyer S, Kudumala S, Schnabl B. Cabré N, et al. Among authors: kouno t. Hepatology. 2023 Jul 1;78(1):295-306. doi: 10.1097/HEP.0000000000000324. Epub 2023 Feb 23. Hepatology. 2023. PMID: 36811393 Free PMC article.
Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types.
Yip CW, Hon CC, Yasuzawa K, Sivaraman DM, Ramilowski JA, Shibayama Y, Agrawal S, Prabhu AV, Parr C, Severin J, Lan YJ, Dostie J, Petri A, Nishiyori-Sueki H, Tagami M, Itoh M, López-Redondo F, Kouno T, Chang JC, Luginbühl J, Kato M, Murata M, Yip WH, Shu X, Abugessaisa I, Hasegawa A, Suzuki H, Kauppinen S, Yagi K, Okazaki Y, Kasukawa T, de Hoon M, Carninci P, Shin JW. Yip CW, et al. Among authors: kouno t. Cell Rep. 2022 Dec 27;41(13):111893. doi: 10.1016/j.celrep.2022.111893. Cell Rep. 2022. PMID: 36577377 Free article.
160 results