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αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. Uboveja A, et al. Among authors: hempel n. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. bioRxiv. 2024. PMID: 38370789 Free PMC article. Preprint.
Development of adaptive anoikis resistance promotes metastasis that can be overcome by CDK8/19 Mediator kinase inhibition.
Monavarian M, Page EF, Rajkarnikar R, Kumari A, Macias LQ, Massicano F, Lee NY, Sahoo S, Hempel N, Jolly MK, Ianov L, Worthey E, Singh A, Broude EV, Mythreye K. Monavarian M, et al. Among authors: hempel n. bioRxiv [Preprint]. 2023 Dec 6:2023.12.04.569970. doi: 10.1101/2023.12.04.569970. bioRxiv. 2023. PMID: 38106208 Free PMC article. Preprint.
GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15.
Chang C, Cheng YY, Kamlapurkar S, White SR, Tang PW, Elhaw AT, Javed Z, Aird KM, Mythreye K, Phaëton R, Hempel N. Chang C, et al. Among authors: hempel n. bioRxiv [Preprint]. 2024 Jan 29:2024.01.24.577037. doi: 10.1101/2024.01.24.577037. bioRxiv. 2024. Update in: Gynecol Oncol. 2024 Jun;185:8-16. doi: 10.1016/j.ygyno.2024.02.004 PMID: 38352432 Free PMC article. Updated. Preprint.
Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.
Choi AS, Jenkins-Lane LM, Barton W, Kumari A, Lancaster C, Raulerson C, Ji H, Altomare D, Starr MD, Whitaker R, Phaeton R, Arend R, Shtutman M, Nixon AB, Hempel N, Lee NY, Mythreye K. Choi AS, et al. Among authors: hempel n. bioRxiv [Preprint]. 2023 Aug 29:2023.08.29.555364. doi: 10.1101/2023.08.29.555364. bioRxiv. 2023. Update in: Cell Commun Signal. 2024 Feb 15;22(1):128. doi: 10.1186/s12964-024-01496-y PMID: 37693479 Free PMC article. Updated. Preprint.
Redox-control of the alarmin, Interleukin-1α.
McCarthy DA, Ranganathan A, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA. McCarthy DA, et al. Among authors: hempel n. Redox Biol. 2013 Apr 17;1(1):218-25. doi: 10.1016/j.redox.2013.03.001. eCollection 2013. Redox Biol. 2013. PMID: 24024155 Free PMC article.
Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.
Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I. Ben-Kasus Nissim T, et al. Among authors: hempel n. EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20. EMBO J. 2017. PMID: 28219928 Free PMC article.
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