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Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder.
Zeng Y, Navarro P, Shirali M, Howard DM, Adams MJ, Hall LS, Clarke TK, Thomson PA, Smith BH, Murray A, Padmanabhan S, Hayward C, Boutin T, MacIntyre DJ, Lewis CM, Wray NR, Mehta D, Penninx BWJH, Milaneschi Y, Baune BT, Air T, Hottenga JJ, Mbarek H, Castelao E, Pistis G, Schulze TG, Streit F, Forstner AJ, Byrne EM, Martin NG, Breen G, Müller-Myhsok B, Lucae S, Kloiber S, Domenici E; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Deary IJ, Porteous DJ, Haley CS, McIntosh AM. Zeng Y, et al. Among authors: clarke tk. Biol Psychiatry. 2017 Sep 1;82(5):312-321. doi: 10.1016/j.biopsych.2016.12.012. Epub 2016 Dec 16. Biol Psychiatry. 2017. PMID: 28153336 Free PMC article.
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Desrivières S, Aliev FA, Khan AA, Amin N, Aulchenko YS, Bakalkin G, Bakker SJ, Balkau B, Beulens JW, Bilbao A, de Boer RA, Beury D, Bots ML, Breetvelt EJ, Cauchi S, Cavalcanti-Proença C, Chambers JC, Clarke TK, Dahmen N, de Geus EJ, Dick D, Ducci F, Easton A, Edenberg HJ, Esko T, Fernández-Medarde A, Foroud T, Freimer NB, Girault JA, Grobbee DE, Guarrera S, Gudbjartsson DF, Hartikainen AL, Heath AC, Hesselbrock V, Hofman A, Hottenga JJ, Isohanni MK, Kaprio J, Khaw KT, Kuehnel B, Laitinen J, Lobbens S, Luan J, Mangino M, Maroteaux M, Matullo G, McCarthy MI, Mueller C, Navis G, Numans ME, Núñez A, Nyholt DR, Onland-Moret CN, Oostra BA, O'Reilly PF, Palkovits M, Penninx BW, Polidoro S, Pouta A, Prokopenko I, Ricceri F, Santos E, Smit JH, Soranzo N, Song K, Sovio U, Stumvoll M, Surakk I, Thorgeirsson TE, Thorsteinsdottir U, Troakes C, Tyrfingsson T, Tönjes A, Uiterwaal CS, Uitterlinden AG, van der Harst P, van der Schouw YT, Staehlin O, Vogelzangs N, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Whitfield JB, Wichmann EH, Willemsen G, Witteman JC, Yuan X, Zhai G, Zhao JH, Zhang W, Martin NG, Metspalu A, D… See abstract for full author list ➔ Schumann G, et al. Among authors: clarke tk. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24. doi: 10.1073/pnas.1017288108. Epub 2011 Apr 6. Proc Natl Acad Sci U S A. 2011. PMID: 21471458 Free PMC article.
Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking.
Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, Desrivieres S, Clarke TK, Lourdusamy A, Smolka MN, Cichon S, Blomeyer D, Treutlein J, Perreau-Lenz S, Witt S, Leonardi-Essmann F, Wodarz N, Zill P, Soyka M, Albrecht U, Rietschel M, Lathrop M, Bakalkin G, Spanagel R, Schumann G. Dong L, et al. Among authors: clarke tk. Am J Psychiatry. 2011 Oct;168(10):1090-8. doi: 10.1176/appi.ajp.2011.10111579. Epub 2011 Aug 9. Am J Psychiatry. 2011. PMID: 21828288 Free article.
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
Clarke TK, Smith AH, Gelernter J, Kranzler HR, Farrer LA, Hall LS, Fernandez-Pujals AM, MacIntyre DJ, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, Thomson PA, Porteous DJ, Deary IJ, McIntosh AM. Clarke TK, et al. Addict Biol. 2016 Mar;21(2):469-80. doi: 10.1111/adb.12245. Epub 2015 Apr 10. Addict Biol. 2016. PMID: 25865819 Free PMC article.
Polygenic risk for coronary artery disease is associated with cognitive ability in older adults.
Hagenaars SP, Harris SE, Clarke TK, Hall L, Luciano M, Fernandez-Pujals AM, Davies G, Hayward C; Generation Scotland; Starr JM, Porteous DJ, McIntosh AM, Deary IJ. Hagenaars SP, et al. Among authors: clarke tk. Int J Epidemiol. 2016 Apr;45(2):433-440. doi: 10.1093/ije/dyv354. Epub 2016 Jan 28. Int J Epidemiol. 2016. PMID: 26822939 Free PMC article.
A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder.
Zeng Y, Navarro P, Fernandez-Pujals AM, Hall LS, Clarke TK, Thomson PA, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, MacIntyre DJ, Wray NR; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Deary IJ, Porteous DJ, Haley CS, McIntosh AM. Zeng Y, et al. Among authors: clarke tk. Biol Psychiatry. 2017 Feb 15;81(4):336-346. doi: 10.1016/j.biopsych.2016.04.017. Epub 2016 May 2. Biol Psychiatry. 2017. PMID: 27422368 Free PMC article.
Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis.
McIntosh AM, Hall LS, Zeng Y, Adams MJ, Gibson J, Wigmore E, Hagenaars SP, Davies G, Fernandez-Pujals AM, Campbell AI, Clarke TK, Hayward C, Haley CS, Porteous DJ, Deary IJ, Smith DJ, Nicholl BI, Hinds DA, Jones AV, Scollen S, Meng W, Smith BH, Hocking LJ. McIntosh AM, et al. Among authors: clarke tk. PLoS Med. 2016 Aug 16;13(8):e1002090. doi: 10.1371/journal.pmed.1002090. eCollection 2016 Aug. PLoS Med. 2016. PMID: 27529168 Free PMC article.
Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression.
Zeng Y, Navarro P, Xia C, Amador C, Fernandez-Pujals AM, Thomson PA, Campbell A, Nagy R, Clarke TK, Hafferty JD, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, MacIntyre DJ, Porteous DJ, Haley CS, McIntosh AM. Zeng Y, et al. Among authors: clarke tk. EBioMedicine. 2016 Dec;14:161-167. doi: 10.1016/j.ebiom.2016.11.003. Epub 2016 Nov 4. EBioMedicine. 2016. PMID: 27838479 Free PMC article.
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z, Lahti J, Langenberg C, Lehtimäki T, Liu Y, Madden PA, Martin N, Morrison A, Penninx B, Pirastu N, Psaty B, Raitakari O, Ridker P, Rose R, Rotter JI, Samani NJ, Schmidt H, Spector TD, Stott D, Strachan D, Tzoulaki I, van der Har… See abstract for full author list ➔ Schumann G, et al. Among authors: clarke tk. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377. doi: 10.1073/pnas.1611243113. Epub 2016 Nov 28. Proc Natl Acad Sci U S A. 2016. PMID: 27911795 Free PMC article.
151 results