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Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time.
Dogné JM, Hanson J, de Leval X, Kolh P, Tchana-Sato V, de Leval L, Rolin S, Ghuysen A, Segers P, Lambermont B, Masereel B, Pirotte B. Dogné JM, et al. Among authors: pirotte b. J Pharmacol Exp Ther. 2004 May;309(2):498-505. doi: 10.1124/jpet.103.063610. Epub 2004 Jan 23. J Pharmacol Exp Ther. 2004. PMID: 14742735
New developments on thromboxane modulators.
Dogné JM, Hanson J, de Leval X, Masereel B, Kolh P, Pirotte B. Dogné JM, et al. Among authors: pirotte b. Mini Rev Med Chem. 2004 Aug;4(6):649-57. doi: 10.2174/1389557043403684. Mini Rev Med Chem. 2004. PMID: 15279599 Review.
Progress in the field of GPIIb/IIIa antagonists.
Hanson J, de Leval X, David JL, Supuran C, Pirotte B, Dogné JM. Hanson J, et al. Among authors: pirotte b. Curr Med Chem Cardiovasc Hematol Agents. 2004 Apr;2(2):157-67. doi: 10.2174/1568016043477224. Curr Med Chem Cardiovasc Hematol Agents. 2004. PMID: 15320798 Review.
In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.
Hanson J, Rolin S, Reynaud D, Qiao N, Kelley LP, Reid HM, Valentin F, Tippins J, Kinsella BT, Masereel B, Pace-Asciak C, Pirotte B, Dogné JM. Hanson J, et al. Among authors: pirotte b. J Pharmacol Exp Ther. 2005 Apr;313(1):293-301. doi: 10.1124/jpet.104.079301. Epub 2004 Dec 30. J Pharmacol Exp Ther. 2005. PMID: 15626721
From the design to the clinical application of thromboxane modulators.
Dogné JM, Hanson J, de Leval X, Pratico D, Pace-Asciak CR, Drion P, Pirotte B, Ruan KH. Dogné JM, et al. Among authors: pirotte b. Curr Pharm Des. 2006;12(8):903-23. doi: 10.2174/138161206776055921. Curr Pharm Des. 2006. PMID: 16533159 Review.
Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
Hanson J, Reynaud D, Qiao N, Devel P, Moray AL, Renard JF, Kelley LP, Winum JY, Montero JL, Kinsella BT, Pirotte B, Pace-Asciak CR, Dogné JM. Hanson J, et al. Among authors: pirotte b. J Med Chem. 2006 Jun 15;49(12):3701-9. doi: 10.1021/jm060108a. J Med Chem. 2006. PMID: 16759113
251 results