Hothersall J - Search Results

1

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Gao SS, Wang L, Song Z, Hothersall J, Stevens ER, Connolly J, Winn PJ, Cox RJ, Crump MP, Race PR, Thomas CM, Simpson TJ, Willis CL. Gao SS, et al. Among authors: hothersall j. Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3930-3934. doi: 10.1002/anie.201611590. Epub 2017 Feb 9. Angew Chem Int Ed Engl. 2017. PMID: 28181382

2

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

El-Sayed AK, Hothersall J, Cooper SM, Stephens E, Simpson TJ, Thomas CM. El-Sayed AK, et al. Among authors: hothersall j. Chem Biol. 2003 May;10(5):419-30. doi: 10.1016/s1074-5521(03)00091-7. Chem Biol. 2003. PMID: 12770824

3

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.

Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Laosripaiboon W, Simpson TJ, Thomas CM. Cooper SM, et al. Among authors: hothersall j. Chem Commun (Camb). 2005 Mar 7;(9):1179-81. doi: 10.1039/b414781b. Epub 2005 Jan 17. Chem Commun (Camb). 2005. PMID: 15726184

4

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

Cooper SM, Laosripaiboon W, Rahman AS, Hothersall J, El-Sayed AK, Winfield C, Crosby J, Cox RJ, Simpson TJ, Thomas CM. Cooper SM, et al. Among authors: hothersall j. Chem Biol. 2005 Jul;12(7):825-33. doi: 10.1016/j.chembiol.2005.05.015. Chem Biol. 2005. PMID: 16039529

5

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

Wu J, Hothersall J, Mazzetti C, O'Connell Y, Shields JA, Rahman AS, Cox RJ, Crosby J, Simpson TJ, Thomas CM, Willis CL. Wu J, et al. Among authors: hothersall j. Chembiochem. 2008 Jun 16;9(9):1500-8. doi: 10.1002/cbic.200800085. Chembiochem. 2008. PMID: 18465759

6

Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster.

Shields JA, Rahman AS, Arthur CJ, Crosby J, Hothersall J, Simpson TJ, Thomas CM. Shields JA, et al. Among authors: hothersall j. Chembiochem. 2010 Jan 25;11(2):248-55. doi: 10.1002/cbic.200900565. Chembiochem. 2010. PMID: 20013982

7

Resistance to and synthesis of the antibiotic mupirocin.

Thomas CM, Hothersall J, Willis CL, Simpson TJ. Thomas CM, et al. Among authors: hothersall j. Nat Rev Microbiol. 2010 Apr;8(4):281-9. doi: 10.1038/nrmicro2278. Epub 2010 Mar 1. Nat Rev Microbiol. 2010. PMID: 20190824 Review.

8

Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.

Hothersall J, Murphy AC, Iqbal Z, Campbell G, Stephens ER, Wu J, Cooper H, Atkinson S, Williams P, Crosby J, Willis CL, Cox RJ, Simpson TJ, Thomas CM. Hothersall J, et al. Appl Microbiol Biotechnol. 2011 May;90(3):1017-26. doi: 10.1007/s00253-011-3145-2. Epub 2011 Feb 12. Appl Microbiol Biotechnol. 2011. PMID: 21318358

9

Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudoalteromonas SANK73390.

Murphy AC, Fukuda D, Song Z, Hothersall J, Cox RJ, Willis CL, Thomas CM, Simpson TJ. Murphy AC, et al. Among authors: hothersall j. Angew Chem Int Ed Engl. 2011 Mar 28;50(14):3271-4. doi: 10.1002/anie.201007029. Epub 2011 Mar 4. Angew Chem Int Ed Engl. 2011. PMID: 21381163 No abstract available.

10

A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.

Fukuda D, Haines AS, Song Z, Murphy AC, Hothersall J, Stephens ER, Gurney R, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM. Fukuda D, et al. Among authors: hothersall j. PLoS One. 2011 Mar 31;6(3):e18031. doi: 10.1371/journal.pone.0018031. PLoS One. 2011. PMID: 21483852 Free PMC article.

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