Leask A - Search Results

1

Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex.

Ercan E, Han JM, Di Nardo A, Winden K, Han MJ, Hoyo L, Saffari A, Leask A, Geschwind DH, Sahin M. Ercan E, et al. Among authors: leask a. J Exp Med. 2017 Mar 6;214(3):681-697. doi: 10.1084/jem.20160446. Epub 2017 Feb 9. J Exp Med. 2017. PMID: 28183733 Free PMC article.

2

CCN2 is necessary for the function of mouse embryonic fibroblasts.

Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. Kennedy L, et al. Among authors: leask a. Exp Cell Res. 2007 Mar 10;313(5):952-64. doi: 10.1016/j.yexcr.2006.12.006. Epub 2006 Dec 23. Exp Cell Res. 2007. PMID: 17239853

3

Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes.

Woods A, Pala D, Kennedy L, McLean S, Rockel JS, Wang G, Leask A, Beier F. Woods A, et al. Among authors: leask a. Osteoarthritis Cartilage. 2009 Mar;17(3):406-13. doi: 10.1016/j.joca.2008.07.002. Epub 2008 Aug 29. Osteoarthritis Cartilage. 2009. PMID: 18760941 Free article.

4

Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2.

Liu S, Parapuram SK, Leask A. Liu S, et al. Among authors: leask a. Arthritis Rheum. 2013 Nov;65(11):2940-4. doi: 10.1002/art.38121. Arthritis Rheum. 2013. PMID: 23983074 Free article.

5

CCN2 modulates hair follicle cycling in mice.

Liu S, Leask A. Liu S, et al. Among authors: leask a. Mol Biol Cell. 2013 Dec;24(24):3939-44. doi: 10.1091/mbc.E13-08-0472. Epub 2013 Oct 23. Mol Biol Cell. 2013. PMID: 24152728 Free PMC article.

6

CCN2 expression by fibroblasts is not required for cutaneous tissue repair.

Liu S, Thompson K, Leask A. Liu S, et al. Among authors: leask a. Wound Repair Regen. 2014 Jan-Feb;22(1):119-24. doi: 10.1111/wrr.12131. Wound Repair Regen. 2014. PMID: 24393160

7

Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism.

Parapuram SK, Thompson K, Tsang M, Hutchenreuther J, Bekking C, Liu S, Leask A. Parapuram SK, et al. Among authors: leask a. Matrix Biol. 2015 Apr;43:35-41. doi: 10.1016/j.matbio.2015.01.017. Epub 2015 Jan 30. Matrix Biol. 2015. PMID: 25644104

8

CCN2 in Skin Fibrosis.

Leask A. Leask A. Methods Mol Biol. 2017;1489:417-421. doi: 10.1007/978-1-4939-6430-7_34. Methods Mol Biol. 2017. PMID: 27734393

9

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis.

Makino K, Makino T, Stawski L, Lipson KE, Leask A, Trojanowska M. Makino K, et al. Among authors: leask a. Arthritis Res Ther. 2017 Jun 13;19(1):134. doi: 10.1186/s13075-017-1356-3. Arthritis Res Ther. 2017. PMID: 28610597 Free PMC article.

10

Genetic manipulation of CCN2/CTGF unveils cell-specific ECM-remodeling effects in injured skeletal muscle.

Petrosino JM, Leask A, Accornero F. Petrosino JM, et al. Among authors: leask a. FASEB J. 2019 Feb;33(2):2047-2057. doi: 10.1096/fj.201800622RR. Epub 2018 Sep 14. FASEB J. 2019. PMID: 30216109 Free PMC article.

To address this question, a conditional Ctgf myofiber and fibroblast-knockout mouse lines were generated and crossed to a dystrophic background. ...Our results show that the myofibers are critical mediators of the deleterious effects associated with CTGF in MD and a …

To address this question, a conditional Ctgf myofiber and fibroblast-knockout mouse lines were generated and crossed to a dyst …

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