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Page 1
Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial.
Curry J, Johnson J, Tassone P, Vidal MD, Menezes DW, Sprandio J, Mollaee M, Cotzia P, Birbe R, Lin Z, Gill K, Duddy E, Zhan T, Leiby B, Reyzer M, Cognetti D, Luginbuhl A, Tuluc M, Martinez-Outschoorn U. Curry J, et al. Laryngoscope. 2017 Aug;127(8):1808-1815. doi: 10.1002/lary.26489. Epub 2017 Feb 10. Laryngoscope. 2017. PMID: 28185288 Free PMC article. Clinical Trial.
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F. Martinez-Outschoorn UE, et al. Cell Cycle. 2010 Sep 1;9(17):3515-33. doi: 10.4161/cc.9.17.12928. Epub 2010 Sep 9. Cell Cycle. 2010. PMID: 20855962 Free PMC article.
Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment.
Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, Pavlides S, Whitaker-Menezes D, Tsirigos A, Witkiewicz A, Lin Z, Balliet R, Howell A, Sotgia F. Lisanti MP, et al. Cancer Biol Ther. 2010 Sep 15;10(6):537-42. doi: 10.4161/cbt.10.6.13370. Epub 2010 Sep 19. Cancer Biol Ther. 2010. PMID: 20861671 Free PMC article. Review.
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.
Martinez-Outschoorn UE, Prisco M, Ertel A, Tsirigos A, Lin Z, Pavlides S, Wang C, Flomenberg N, Knudsen ES, Howell A, Pestell RG, Sotgia F, Lisanti MP. Martinez-Outschoorn UE, et al. Cell Cycle. 2011 Apr 15;10(8):1271-86. doi: 10.4161/cc.10.8.15330. Cell Cycle. 2011. PMID: 21512313 Free PMC article.
Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.
Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP. Whitaker-Menezes D, et al. Cell Cycle. 2011 Jun 1;10(11):1772-83. doi: 10.4161/cc.10.11.15659. Epub 2011 Jun 1. Cell Cycle. 2011. PMID: 21558814 Free PMC article.
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
Martinez-Outschoorn UE, Goldberg A, Lin Z, Ko YH, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A, Sotgia F, Lisanti MP. Martinez-Outschoorn UE, et al. Cancer Biol Ther. 2011 Nov 15;12(10):924-38. doi: 10.4161/cbt.12.10.17780. Epub 2011 Nov 15. Cancer Biol Ther. 2011. PMID: 22041887 Free PMC article.
141 results