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Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.
Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Stastna E, et al. Among authors: chen zw. J Med Chem. 2011 Jun 9;54(11):3926-34. doi: 10.1021/jm2002487. Epub 2011 May 6. J Med Chem. 2011. PMID: 21504158 Free PMC article.
A propofol binding site on mammalian GABAA receptors identified by photolabeling.
Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP. Yip GM, et al. Among authors: chen zw. Nat Chem Biol. 2013 Nov;9(11):715-20. doi: 10.1038/nchembio.1340. Epub 2013 Sep 22. Nat Chem Biol. 2013. PMID: 24056400 Free PMC article.
11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.
Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS. Chen ZW, et al. Psychopharmacology (Berl). 2014 Sep;231(17):3479-91. doi: 10.1007/s00213-014-3568-4. Epub 2014 Apr 23. Psychopharmacology (Berl). 2014. PMID: 24756762 Free PMC article.
952 results