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The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.
Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M. Di Conza G, et al. Among authors: mazzone m. Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051. Cell Rep. 2017. PMID: 28199842 Free PMC article.
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P. Mazzone M, et al. Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12. Cell. 2009. PMID: 19217150 Free PMC article.
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M. Takeda Y, et al. Among authors: mazzone m. Nature. 2011 Oct 9;479(7371):122-6. doi: 10.1038/nature10507. Nature. 2011. PMID: 21983962 Free PMC article.
Overcoming resistance to antiangiogenic therapies.
Tejpar S, Prenen H, Mazzone M. Tejpar S, et al. Among authors: mazzone m. Oncologist. 2012;17(8):1039-50. doi: 10.1634/theoncologist.2012-0068. Epub 2012 Jul 6. Oncologist. 2012. PMID: 22773560 Free PMC article. Review.
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity.
Leite de Oliveira R, Deschoemaeker S, Henze AT, Debackere K, Finisguerra V, Takeda Y, Roncal C, Dettori D, Tack E, Jönsson Y, Veschini L, Peeters A, Anisimov A, Hofmann M, Alitalo K, Baes M, D'hooge J, Carmeliet P, Mazzone M. Leite de Oliveira R, et al. Among authors: mazzone m. Cancer Cell. 2012 Aug 14;22(2):263-77. doi: 10.1016/j.ccr.2012.06.028. Cancer Cell. 2012. PMID: 22897855 Free article.
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, Movahedi K, Houbracken I, Schouppe E, Elkrim Y, Karroum O, Jordan B, Carmeliet P, Gysemans C, De Baetselier P, Mazzone M, Van Ginderachter JA. Laoui D, et al. Among authors: mazzone m. Cancer Res. 2014 Jan 1;74(1):24-30. doi: 10.1158/0008-5472.CAN-13-1196. Epub 2013 Nov 12. Cancer Res. 2014. PMID: 24220244
Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer.
Hamm A, Prenen H, Van Delm W, Di Matteo M, Wenes M, Delamarre E, Schmidt T, Weitz J, Sarmiento R, Dezi A, Gasparini G, Rothé F, Schmitz R, D'Hoore A, Iserentant H, Hendlisz A, Mazzone M. Hamm A, et al. Among authors: mazzone m. Gut. 2016 Jun;65(6):990-1000. doi: 10.1136/gutjnl-2014-308988. Epub 2015 Mar 26. Gut. 2016. PMID: 25814648
MET is required for the recruitment of anti-tumoural neutrophils.
Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AA, Wauters E, Walmsley S, Prenen H, Granot Z, Casazza A, Mazzone M. Finisguerra V, et al. Among authors: mazzone m. Nature. 2015 Jun 18;522(7556):349-53. doi: 10.1038/nature14407. Epub 2015 May 18. Nature. 2015. PMID: 25985180 Free PMC article.
294 results