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Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas.
Abou-El-Ardat K, Seifert M, Becker K, Eisenreich S, Lehmann M, Hackmann K, Rump A, Meijer G, Carvalho B, Temme A, Schackert G, Schröck E, Krex D, Klink B. Abou-El-Ardat K, et al. Neuro Oncol. 2017 Apr 1;19(4):546-557. doi: 10.1093/neuonc/now231. Neuro Oncol. 2017. PMID: 28201779 Free PMC article.
Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.
Eisenreich S, Abou-El-Ardat K, Szafranski K, Campos Valenzuela JA, Rump A, Nigro JM, Bjerkvig R, Gerlach EM, Hackmann K, Schröck E, Krex D, Kaderali L, Schackert G, Platzer M, Klink B. Eisenreich S, et al. PLoS One. 2013 Sep 27;8(9):e76623. doi: 10.1371/journal.pone.0076623. eCollection 2013. PLoS One. 2013. PMID: 24086756 Free PMC article.
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.
Exner ND, Valenzuela JAC, Abou-El-Ardat K, Miletic H, Huszthy PC, Radehaus PM, Schröck E, Bjerkvig R, Kaderali L, Klink B, Nigro JM. Exner ND, et al. Among authors: abou el ardat k. Oncotarget. 2019 Jun 4;10(38):3641-3653. doi: 10.18632/oncotarget.26950. eCollection 2019 Jun 4. Oncotarget. 2019. PMID: 31217899 Free PMC article.
Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin.
Biedermann J, Preussler M, Conde M, Peitzsch M, Richter S, Wiedemuth R, Abou-El-Ardat K, Krüger A, Meinhardt M, Schackert G, Leenders WP, Herold-Mende C, Niclou SP, Bjerkvig R, Eisenhofer G, Temme A, Seifert M, Kunz-Schughart LA, Schröck E, Klink B. Biedermann J, et al. Among authors: abou el ardat k. Cancers (Basel). 2019 Dec 16;11(12):2028. doi: 10.3390/cancers11122028. Cancers (Basel). 2019. PMID: 31888244 Free PMC article.
Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.
Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Abou-El-Ardat K, Kiefer KC, Hoffmann J, Seeger F, Bonig H, Dimmeler S, Zeiher AM, Rieger MA. Dorsheimer L, et al. Among authors: abou el ardat k. Haematologica. 2020 Jul;105(7):e328-e332. doi: 10.3324/haematol.2019.224402. Epub 2019 Nov 7. Haematologica. 2020. PMID: 31699791 Free PMC article. No abstract available.
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
Kiefer KC, Cremer S, Pardali E, Assmus B, Abou-El-Ardat K, Kirschbaum K, Dorsheimer L, Rasper T, Berkowitsch A, Serve H, Dimmeler S, Zeiher AM, Rieger MA. Kiefer KC, et al. Among authors: abou el ardat k. ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28. ESC Heart Fail. 2021. PMID: 33779075 Free PMC article.
Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.
Ortmann CA, Dorsheimer L, Abou-El-Ardat K, Hoffrichter J, Assmus B, Bonig H, Scholz A, Pfeifer H, Martin H, Schmid T, Brüne B, Scheich S, Steffen B, Riemann J, Hermann S, Dukat A, Bug G, Brandts CH, Wagner S, Serve H, Rieger MA. Ortmann CA, et al. Cell Rep. 2019 May 14;27(7):2022-2028.e3. doi: 10.1016/j.celrep.2019.04.064. Cell Rep. 2019. PMID: 31091442 Free article. Clinical Trial.
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.
Malkomes P, Lunger I, Oppermann E, Abou-El-Ardat K, Oellerich T, Günther S, Canbulat C, Bothur S, Schnütgen F, Yu W, Wingert S, Haetscher N, Catapano C, Dietz MS, Heilemann M, Kvasnicka HM, Holzer K, Serve H, Bechstein WO, Rieger MA. Malkomes P, et al. Among authors: abou el ardat k. Oncogene. 2021 Jun;40(25):4352-4367. doi: 10.1038/s41388-021-01847-w. Epub 2021 Jun 8. Oncogene. 2021. PMID: 34103685 Free PMC article.
27 results