Tojo A - Search Results

1

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells.

Sasahara A, Tominaga K, Nishimura T, Yano M, Kiyokawa E, Noguchi M, Noguchi M, Kanauchi H, Ogawa T, Minato H, Tada K, Seto Y, Tojo A, Gotoh N. Sasahara A, et al. Among authors: tojo a. Oncotarget. 2017 Apr 11;8(15):24869-24881. doi: 10.18632/oncotarget.15276. Oncotarget. 2017. PMID: 28206960 Free PMC article.

2

A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor.

Gotoh N, Tojo A, Hino M, Yazaki Y, Shibuya M. Gotoh N, et al. Among authors: tojo a. Biochem Biophys Res Commun. 1992 Jul 31;186(2):768-74. doi: 10.1016/0006-291x(92)90812-y. Biochem Biophys Res Commun. 1992. PMID: 1323290

3

Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.

Gotoh N, Tojo A, Muroya K, Hashimoto Y, Hattori S, Nakamura S, Takenawa T, Yazaki Y, Shibuya M. Gotoh N, et al. Among authors: tojo a. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):167-71. doi: 10.1073/pnas.91.1.167. Proc Natl Acad Sci U S A. 1994. PMID: 7506413 Free PMC article.

4

A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3.

Gotoh N, Tojo A, Shibuya M. Gotoh N, et al. Among authors: tojo a. EMBO J. 1996 Nov 15;15(22):6197-204. EMBO J. 1996. PMID: 8947042 Free PMC article.

5

Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells.

Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Gotoh N. Murohashi M, et al. Among authors: tojo a. Br J Cancer. 2010 Jan 5;102(1):206-12. doi: 10.1038/sj.bjc.6605468. Epub 2009 Dec 8. Br J Cancer. 2010. PMID: 19997106 Free PMC article.

6

ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer.

Hinohara K, Kobayashi S, Kanauchi H, Shimizu S, Nishioka K, Tsuji E, Tada K, Umezawa K, Mori M, Ogawa T, Inoue J, Tojo A, Gotoh N. Hinohara K, et al. Among authors: tojo a. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6584-9. doi: 10.1073/pnas.1113271109. Epub 2012 Apr 5. Proc Natl Acad Sci U S A. 2012. PMID: 22492965 Free PMC article.

7

Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs.

Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama M, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N. Nakata A, et al. Among authors: tojo a. Sci Rep. 2015 Aug 13;5:13076. doi: 10.1038/srep13076. Sci Rep. 2015. PMID: 26268703 Free PMC article.

8

Oncogenic Fusion Gene CD74-NRG1 Confers Cancer Stem Cell-like Properties in Lung Cancer through a IGF2 Autocrine/Paracrine Circuit.

Murayama T, Nakaoku T, Enari M, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T, Gotoh N. Murayama T, et al. Among authors: tojo a. Cancer Res. 2016 Feb 15;76(4):974-83. doi: 10.1158/0008-5472.CAN-15-2135. Epub 2016 Feb 2. Cancer Res. 2016. PMID: 26837769 Free article.

9

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.

Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N. Tominaga K, et al. Among authors: tojo a. Oncogene. 2017 Mar 2;36(9):1276-1286. doi: 10.1038/onc.2016.293. Epub 2016 Aug 22. Oncogene. 2017. PMID: 27546618 Free PMC article.

10

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.

Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N. Nishimura T, et al. Among authors: tojo a. Oncogene. 2019 Apr;38(14):2464-2481. doi: 10.1038/s41388-018-0589-1. Epub 2018 Dec 7. Oncogene. 2019. PMID: 30532069 Free PMC article.

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