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Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.
Schlums H, Jung M, Han H, Theorell J, Bigley V, Chiang SC, Allan DS, Davidson-Moncada JK, Dickinson RE, Holmes TD, Hsu AP, Townsley D, Winkler T, Wang W, Aukrust P, Nordøy I, Calvo KR, Holland SM, Collin M, Dunbar CE, Bryceson YT. Schlums H, et al. Among authors: han h. Blood. 2017 Apr 6;129(14):1927-1939. doi: 10.1182/blood-2016-08-734236. Epub 2017 Feb 16. Blood. 2017. PMID: 28209719 Free PMC article.
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, Han H, Chiang SC, Foley B, Mattsson K, Larsson S, Schaffer M, Malmberg KJ, Ljunggren HG, Miller JS, Bryceson YT. Schlums H, et al. Among authors: han h. Immunity. 2015 Mar 17;42(3):443-56. doi: 10.1016/j.immuni.2015.02.008. Immunity. 2015. PMID: 25786176 Free PMC article.
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.
Holmes TD, Pandey RV, Helm EY, Schlums H, Han H, Campbell TM, Drashansky TT, Chiang S, Wu CY, Tao C, Shoukier M, Tolosa E, Von Hardenberg S, Sun M, Klemann C, Marsh RA, Lau CM, Lin Y, Sun JC, Månsson R, Cichocki F, Avram D, Bryceson YT. Holmes TD, et al. Among authors: han h. Sci Immunol. 2021 Mar 12;6(57):eabc9801. doi: 10.1126/sciimmunol.abc9801. Sci Immunol. 2021. PMID: 33712472 Free PMC article.
Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity.
Kavazović I, Han H, Balzaretti G, Slinger E, Lemmermann NAW, Ten Brinke A, Merkler D, Koster J, Bryceson YT, de Vries N, Jonjić S, Klarenbeek PL, Polić B, Eldering E, Wensveen FM. Kavazović I, et al. Among authors: han h. PLoS Biol. 2020 Mar 17;18(3):e3000648. doi: 10.1371/journal.pbio.3000648. eCollection 2020 Mar. PLoS Biol. 2020. PMID: 32182234 Free PMC article.
Patients with both Langerhans cell histiocytosis and Crohn's disease highlight a common role of interleukin-23.
Kvedaraite E, Lourda M, Han H, Tesi B, Mitchell J, Ideström M, Mouratidou N, Rassidakis G, von Bahr Greenwood T, Cohen-Aubart F, Jädersten M, Åkefeldt SO, Svensson M, Kannourakis G, Bryceson YT, Haroche J, Henter JI. Kvedaraite E, et al. Among authors: han h. Acta Paediatr. 2021 Apr;110(4):1315-1321. doi: 10.1111/apa.15590. Epub 2020 Oct 8. Acta Paediatr. 2021. PMID: 32975844 Free PMC article.
Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation.
Han H, Liang X, Ekberg M, Kritikou JS, Brunnström Å, Pelcman B, Matl M, Miao X, Andersson M, Yuan X, Schain F, Parvin S, Melin E, Sjöberg J, Xu D, Westerberg LS, Björkholm M, Claesson HE. Han H, et al. FASEB J. 2017 Feb;31(2):491-504. doi: 10.1096/fj.201600679RR. Epub 2016 Oct 17. FASEB J. 2017. PMID: 27825104
These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues and decreasing the inflammatory response attenuating symptoms of certain immunologic and inflammatory disorders such as dermatitis.-Han …
These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues an …
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