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CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ. Spencer DH, et al. Among authors: helton nm. Cell. 2017 Feb 23;168(5):801-816.e13. doi: 10.1016/j.cell.2017.01.021. Epub 2017 Feb 16. Cell. 2017. PMID: 28215704 Free PMC article.
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ. Spencer DH, et al. Among authors: helton nm. Leukemia. 2015 Jun;29(6):1279-89. doi: 10.1038/leu.2015.6. Epub 2015 Jan 20. Leukemia. 2015. PMID: 25600023 Free PMC article.
Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC. Wong TN, et al. Among authors: helton nm. Blood. 2016 Feb 18;127(7):893-7. doi: 10.1182/blood-2015-10-677021. Epub 2015 Dec 2. Blood. 2016. PMID: 26631115 Free PMC article.
Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.
Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA. Zhang J, et al. Among authors: helton nm. Exp Hematol. 2017 Nov;55:19-33. doi: 10.1016/j.exphem.2017.07.008. Epub 2017 Jul 28. Exp Hematol. 2017. PMID: 28760689 Free PMC article.
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, Ley TJ. Cole CB, et al. Among authors: helton nm. J Clin Invest. 2017 Oct 2;127(10):3657-3674. doi: 10.1172/JCI93041. Epub 2017 Sep 5. J Clin Invest. 2017. PMID: 28872462 Free PMC article.
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC. Wong TN, et al. Among authors: helton nm. Nat Commun. 2018 Jan 31;9(1):455. doi: 10.1038/s41467-018-02858-0. Nat Commun. 2018. PMID: 29386642 Free PMC article.
Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.
Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight ER, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Ramakrishnan SM, Chang GS, Petti AA, Spencer DH, Miller CA, Ley TJ. Ketkar S, et al. Among authors: helton nm. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3123-3134. doi: 10.1073/pnas.1918611117. Epub 2020 Jan 29. Proc Natl Acad Sci U S A. 2020. PMID: 31996479 Free PMC article.
25 results