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Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.
Liu S, Liu Y, Wang H, Ding Y, Wu H, Dong J, Wong A, Chen SH, Li G, Chan M, Sawyer N, Gervais FG, Henault M, Kargman S, Bedard LL, Han Y, Friesen R, Lobell RB, Stout DM. Liu S, et al. Among authors: chen sh. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5741-5. doi: 10.1016/j.bmcl.2009.08.014. Epub 2009 Aug 7. Bioorg Med Chem Lett. 2009. PMID: 19713110
Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.
Wang J, Shen W, Yuan Z, Lan L, Xu J, Wang C, Ma G, Shi W, Han L, Zhang Z, Hou L, Shen L, Jiang Z, He H, Xiao W, Wang Z, Guo Q, Li J, Chen S. Wang J, et al. Among authors: chen s. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2844-8. doi: 10.1016/j.bmcl.2015.04.100. Epub 2015 May 11. Bioorg Med Chem Lett. 2015. PMID: 26009165
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71.
Wu C, Zhang L, Li P, Cai Q, Peng X, Yin K, Chen X, Ren H, Zhong S, Weng Y, Guan Y, Chen S, Wu J, Li J, Lin T. Wu C, et al. Among authors: chen s, chen x. Biochim Biophys Acta. 2016 Jun;1860(6):1299-307. doi: 10.1016/j.bbagen.2016.03.017. Epub 2016 Mar 15. Biochim Biophys Acta. 2016. PMID: 26987809
Design, synthesis, and biological evaluation of anti-EV71 agents.
Li P, Yang B, Hao F, Wang P, He H, Huang L, Zhang X, Zhang S, Peng X, Yin K, Hu J, Chen X, Gu Z, Wang L, Shen L, Hu G, Li N, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Zhang L, Cai Q, Lin T. Li P, et al. Among authors: chen s, chen x. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3346-3350. doi: 10.1016/j.bmcl.2016.05.036. Epub 2016 May 14. Bioorg Med Chem Lett. 2016. PMID: 27234148
Discovery and Assessment of Atropisomers of (±)-Lesinurad.
Wang J, Zeng W, Li S, Shen L, Gu Z, Zhang Y, Li J, Chen S, Jia X. Wang J, et al. Among authors: chen s. ACS Med Chem Lett. 2017 Feb 14;8(3):299-303. doi: 10.1021/acsmedchemlett.6b00465. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337320 Free PMC article.
Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping.
Wang Y, Chen Z, Dai M, Sun P, Wang C, Gao Y, Zhao H, Zeng W, Shen L, Mao W, Wang T, Hu G, Li J, Chen S, Long C, Chen X, Liu J, Zhang Y. Wang Y, et al. Among authors: chen z, chen s, chen x. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2420-2423. doi: 10.1016/j.bmcl.2017.04.014. Epub 2017 Apr 5. Bioorg Med Chem Lett. 2017. PMID: 28433531
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