Najmanovich RJ - Search Results

1

Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.

St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É. St-Georges C, et al. Among authors: najmanovich rj. Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11. Eur J Med Chem. 2017. PMID: 28219045

2

Design and synthesis of potent, selective inhibitors of matriptase.

Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. Colombo E, et al. ACS Med Chem Lett. 2012 Apr 11;3(7):530-4. doi: 10.1021/ml3000534. eCollection 2012 Jul 12. ACS Med Chem Lett. 2012. PMID: 24900505 Free PMC article.

3

Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.

Duchêne D, Colombo E, Désilets A, Boudreault PL, Leduc R, Marsault E, Najmanovich R. Duchêne D, et al. J Med Chem. 2014 Dec 11;57(23):10198-204. doi: 10.1021/jm5015633. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25387268

4

Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.

Yan LH, Le Roux A, Boyapelly K, Lamontagne AM, Archambault MA, Picard-Jean F, Lalonde-Seguin D, St-Pierre E, Najmanovich RJ, Fortier LC, Lafontaine D, Marsault É. Yan LH, et al. Among authors: najmanovich rj. Eur J Med Chem. 2018 Jan 1;143:755-768. doi: 10.1016/j.ejmech.2017.11.079. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29220796

5

Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines.

Dion SP, Béliveau F, Morency LP, Désilets A, Najmanovich R, Leduc R. Dion SP, et al. Sci Rep. 2018 Aug 22;8(1):12562. doi: 10.1038/s41598-018-30618-z. Sci Rep. 2018. PMID: 30135444 Free PMC article.

6

Side-chain rotamer changes upon ligand binding: common, crucial, correlate with entropy and rearrange hydrogen bonding.

Gaudreault F, Chartier M, Najmanovich R. Gaudreault F, et al. Bioinformatics. 2012 Sep 15;28(18):i423-i430. doi: 10.1093/bioinformatics/bts395. Bioinformatics. 2012. PMID: 22962462 Free PMC article.

7

StAR-related lipid transfer domain protein 5 binds primary bile acids.

Létourneau D, Lorin A, Lefebvre A, Frappier V, Gaudreault F, Najmanovich R, Lavigne P, LeHoux JG. Létourneau D, et al. J Lipid Res. 2012 Dec;53(12):2677-89. doi: 10.1194/jlr.M031245. Epub 2012 Sep 26. J Lipid Res. 2012. PMID: 23018617 Free PMC article.

8

A coarse-grained elastic network atom contact model and its use in the simulation of protein dynamics and the prediction of the effect of mutations.

Frappier V, Najmanovich RJ. Frappier V, et al. Among authors: najmanovich rj. PLoS Comput Biol. 2014 Apr 24;10(4):e1003569. doi: 10.1371/journal.pcbi.1003569. eCollection 2014 Apr. PLoS Comput Biol. 2014. PMID: 24762569 Free PMC article.

9

A three-way inter-molecular network accounts for the Ca_Vα2δ1-induced functional modulation of the pore-forming Ca_V1.2 subunit.

Briot J, Mailhot O, Bourdin B, Tétreault MP, Najmanovich R, Parent L. Briot J, et al. J Biol Chem. 2018 May 11;293(19):7176-7188. doi: 10.1074/jbc.RA118.001902. Epub 2018 Mar 27. J Biol Chem. 2018. PMID: 29588365 Free PMC article.

10

A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors.

Larocque M, Chénard T, Najmanovich R. Larocque M, et al. BMC Syst Biol. 2014 Oct 15;8:117. doi: 10.1186/s12918-014-0117-z. BMC Syst Biol. 2014. PMID: 25315994 Free PMC article.

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