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Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity.
Mena P, Bresciani L, Brindani N, Ludwig IA, Pereira-Caro G, Angelino D, Llorach R, Calani L, Brighenti F, Clifford MN, Gill CIR, Crozier A, Curti C, Del Rio D. Mena P, et al. Among authors: brindani n. Nat Prod Rep. 2019 May 22;36(5):714-752. doi: 10.1039/c8np00062j. Nat Prod Rep. 2019. PMID: 30468210 Review.
Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease.
Ruotolo R, Minato I, La Vitola P, Artioli L, Curti C, Franceschi V, Brindani N, Amidani D, Colombo L, Salmona M, Forloni G, Donofrio G, Balducci C, Del Rio D, Ottonello S. Ruotolo R, et al. Among authors: brindani n. Mol Nutr Food Res. 2020 Mar;64(5):e1900890. doi: 10.1002/mnfr.201900890. Epub 2020 Jan 16. Mol Nutr Food Res. 2020. PMID: 31914208
5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models.
Angelino D, Carregosa D, Domenech-Coca C, Savi M, Figueira I, Brindani N, Jang S, Lakshman S, Molokin A, Urban JF Jr, Davis CD, Brito MA, Kim KS, Brighenti F, Curti C, Bladé C, Del Bas JM, Stilli D, Solano-Aguilar GI, Santos CND, Del Rio D, Mena P. Angelino D, et al. Among authors: brindani n. Nutrients. 2019 Nov 5;11(11):2678. doi: 10.3390/nu11112678. Nutrients. 2019. PMID: 31694297 Free PMC article.
Organocatalytic, Asymmetric Eliminative [4+2] Cycloaddition of Allylidene Malononitriles with Enals: Rapid Entry to Cyclohexadiene-Embedding Linear and Angular Polycycles.
Brindani N, Rassu G, Dell'Amico L, Zambrano V, Pinna L, Curti C, Sartori A, Battistini L, Casiraghi G, Pelosi G, Greco D, Zanardi F. Brindani N, et al. Angew Chem Int Ed Engl. 2015 Jun 15;54(25):7386-90. doi: 10.1002/anie.201501894. Epub 2015 May 7. Angew Chem Int Ed Engl. 2015. PMID: 25950770
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.
Arencibia JM, Brindani N, Franco-Ulloa S, Nigro M, Kuriappan JA, Ottonello G, Bertozzi SM, Summa M, Girotto S, Bertorelli R, Armirotti A, De Vivo M. Arencibia JM, et al. Among authors: brindani n. J Med Chem. 2020 Apr 9;63(7):3508-3521. doi: 10.1021/acs.jmedchem.9b01760. Epub 2020 Mar 30. J Med Chem. 2020. PMID: 32196342 Free PMC article.
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