Takakusa H - Search Results

1

Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation.

Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Yamamoto Y, Sugiyama D, Takakusa H, Inoue SI. Ogiyama T, et al. Among authors: takakusa h. Bioorg Med Chem. 2017 Apr 1;25(7):2234-2243. doi: 10.1016/j.bmc.2017.02.045. Epub 2017 Feb 27. Bioorg Med Chem. 2017. PMID: 28279560

2

Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.

Nakayama S, Takakusa H, Watanabe A, Miyaji Y, Suzuki W, Sugiyama D, Shiosakai K, Honda K, Okudaira N, Izumi T, Okazaki O. Nakayama S, et al. Among authors: takakusa h. Drug Metab Dispos. 2011 Jul;39(7):1247-54. doi: 10.1124/dmd.111.039180. Epub 2011 Apr 5. Drug Metab Dispos. 2011. PMID: 21467212

3

Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors.

Matsufuji T, Ikeda M, Naito A, Hirouchi M, Takakusa H, Kanda S, Izumi M, Harada J, Shinozuka T. Matsufuji T, et al. Among authors: takakusa h. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5067-70. doi: 10.1016/j.bmcl.2012.05.130. Epub 2012 Jun 19. Bioorg Med Chem Lett. 2012. PMID: 22749869

4

Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents.

Watanabe A, Takakusa H, Kimura T, Inoue S, Kusuhara H, Ando O. Watanabe A, et al. Among authors: takakusa h. Drug Metab Dispos. 2016 Oct;44(10):1608-16. doi: 10.1124/dmd.116.071654. Epub 2016 Jul 28. Drug Metab Dispos. 2016. PMID: 27469000

5

Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys.

Yamada M, Takei M, Suzuki E, Takakusa H, Kotsuma M, Washio T, Murayama N, Inoue SI, Izumi T. Yamada M, et al. Among authors: takakusa h. Xenobiotica. 2017 Dec;47(12):1090-1103. doi: 10.1080/00498254.2016.1263766. Epub 2016 Dec 12. Xenobiotica. 2017. PMID: 27866463

6

Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents.

Watanabe A, Takakusa H, Kimura T, Inoue SI, Kusuhara H, Ando O. Watanabe A, et al. Among authors: takakusa h. Drug Metab Dispos. 2017 Mar;45(3):336-341. doi: 10.1124/dmd.116.073783. Epub 2016 Dec 14. Drug Metab Dispos. 2017. PMID: 27974381

7

Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na_V1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver.

Asano D, Nakamura K, Nishiya Y, Shiozawa H, Takakusa H, Shibayama T, Inoue SI, Shinozuka T, Hamada T, Yahara C, Watanabe N, Yoshinari K. Asano D, et al. Among authors: takakusa h. Drug Metab Dispos. 2023 Jan;51(1):67-80. doi: 10.1124/dmd.122.001000. Epub 2022 Oct 23. Drug Metab Dispos. 2023. PMID: 36273823

8

Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats.

Koyama K, Takahashi M, Nakai N, Takakusa H, Murai T, Hoshi M, Yamamura N, Kobayashi N, Okazaki O. Koyama K, et al. Among authors: takakusa h. Xenobiotica. 2010 Mar;40(3):207-16. doi: 10.3109/00498250903447691. Xenobiotica. 2010. PMID: 20146556

9

Tissue distribution and identification of radioactivity components at elimination phase after oral administration of [¹⁴C]CS-1036, an α-amylase inhibitor, to rats.

Honda T, Takakusa H, Murai T, Izumi T. Honda T, et al. Among authors: takakusa h. Drug Metab Dispos. 2013 May;41(5):1125-33. doi: 10.1124/dmd.112.050617. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454829

10

Quantitative assessment of reactive metabolite formation using 35S-labeled glutathione.

Takakusa H, Masumoto H, Makino C, Okazaki O, Sudo K. Takakusa H, et al. Drug Metab Pharmacokinet. 2009;24(1):100-7. doi: 10.2133/dmpk.24.100. Drug Metab Pharmacokinet. 2009. PMID: 19252339 Free article.

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