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Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.
Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. Czirr E, et al. Among authors: longo fm. J Exp Med. 2017 Apr 3;214(4):1081-1092. doi: 10.1084/jem.20162011. Epub 2017 Mar 15. J Exp Med. 2017. PMID: 28298456 Free PMC article.
Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Knowles JK, et al. Among authors: longo fm. Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29. Neurobiol Aging. 2013. PMID: 23545424 Free PMC article.
Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.
Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM. Nguyen TV, et al. Among authors: longo fm. J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036. J Alzheimers Dis. 2014. PMID: 24898660 Free PMC article.
PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide.
James ML, Belichenko NP, Nguyen TV, Andrews LE, Ding Z, Liu H, Bodapati D, Arksey N, Shen B, Cheng Z, Wyss-Coray T, Gambhir SS, Longo FM, Chin FT. James ML, et al. Among authors: longo fm. J Nucl Med. 2015 Feb;56(2):311-6. doi: 10.2967/jnumed.114.141648. Epub 2015 Jan 22. J Nucl Med. 2015. PMID: 25613536 Free PMC article.
157 results