Shi L - Search Results

1

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D₂ Receptor (D₂R) Biased Agonism.

Bonifazi A, Yano H, Ellenberger MP, Muller L, Kumar V, Zou MF, Cai NS, Guerrero AM, Woods AS, Shi L, Newman AH. Bonifazi A, et al. Among authors: shi l. J Med Chem. 2017 Apr 13;60(7):2890-2907. doi: 10.1021/acs.jmedchem.6b01875. Epub 2017 Mar 16. J Med Chem. 2017. PMID: 28300398 Free PMC article.

2

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum.

Quick M, Yano H, Goldberg NR, Duan L, Beuming T, Shi L, Weinstein H, Javitch JA. Quick M, et al. Among authors: shi l. J Biol Chem. 2006 Sep 8;281(36):26444-54. doi: 10.1074/jbc.M602438200. Epub 2006 Jun 23. J Biol Chem. 2006. PMID: 16798738 Free article.

3

The binding sites for cocaine and dopamine in the dopamine transporter overlap.

Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. Beuming T, et al. Among authors: shi l. Nat Neurosci. 2008 Jul;11(7):780-9. doi: 10.1038/nn.2146. Epub 2008 Jun 22. Nat Neurosci. 2008. PMID: 18568020 Free PMC article.

4

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. Bisgaard H, et al. Among authors: shi l. Neuropharmacology. 2011 Jan;60(1):182-90. doi: 10.1016/j.neuropharm.2010.08.021. Epub 2010 Sep 6. Neuropharmacology. 2011. PMID: 20816875 Free PMC article.

5

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.

Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Chien EY, et al. Among authors: shi l. Science. 2010 Nov 19;330(6007):1091-5. doi: 10.1126/science.1197410. Science. 2010. PMID: 21097933 Free PMC article.

6

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Newman AH, Beuming T, Banala AK, Donthamsetti P, Pongetti K, LaBounty A, Levy B, Cao J, Michino M, Luedtke RR, Javitch JA, Shi L. Newman AH, et al. Among authors: shi l. J Med Chem. 2012 Aug 9;55(15):6689-99. doi: 10.1021/jm300482h. Epub 2012 Jun 7. J Med Chem. 2012. PMID: 22632094 Free PMC article.

7

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Plenge P, et al. Among authors: shi l. J Biol Chem. 2012 Nov 16;287(47):39316-26. doi: 10.1074/jbc.M112.371765. Epub 2012 Sep 24. J Biol Chem. 2012. PMID: 23007398 Free PMC article.

8

A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.

Michino M, Donthamsetti P, Beuming T, Banala A, Duan L, Roux T, Han Y, Trinquet E, Newman AH, Javitch JA, Shi L. Michino M, et al. Among authors: shi l. Mol Pharmacol. 2013 Dec;84(6):854-64. doi: 10.1124/mol.113.087833. Epub 2013 Sep 23. Mol Pharmacol. 2013. PMID: 24061855 Free PMC article.

9

Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design.

Keck TM, Burzynski C, Shi L, Newman AH. Keck TM, et al. Among authors: shi l. Adv Pharmacol. 2014;69:267-300. doi: 10.1016/B978-0-12-420118-7.00007-X. Adv Pharmacol. 2014. PMID: 24484980 Free PMC article. Review.

10

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH. Okunola-Bakare OM, et al. Among authors: shi l. J Med Chem. 2014 Feb 13;57(3):1000-13. doi: 10.1021/jm401754x. Epub 2014 Feb 4. J Med Chem. 2014. PMID: 24494745 Free PMC article.

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