Yan N - Search Results

1

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.

Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd. Sakai T, et al. Among authors: yan n. J Autoimmun. 2017 Jul;81:13-23. doi: 10.1016/j.jaut.2017.03.001. Epub 2017 Mar 18. J Autoimmun. 2017. PMID: 28325644 Free PMC article.

2

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N. Hasan M, et al. Among authors: yan n. Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25. Immunity. 2015. PMID: 26320659 Free PMC article.

3

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex.

Kucej M, Fermaintt CS, Yang K, Irizarry-Caro RA, Yan N. Kucej M, et al. Among authors: yan n. Cell Rep. 2017 Mar 14;18(11):2600-2607. doi: 10.1016/j.celrep.2017.02.051. Cell Rep. 2017. PMID: 28297665 Free PMC article.

4

Immune Diseases Associated with TREX1 and STING Dysfunction.

Yan N. Yan N. J Interferon Cytokine Res. 2017 May;37(5):198-206. doi: 10.1089/jir.2016.0086. J Interferon Cytokine Res. 2017. PMID: 28475463 Free PMC article. Review.

5

STING-associated vasculopathy develops independently of IRF3 in mice.

Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Wu J, Platt DJ, Yan N, Miner JJ. Warner JD, et al. Among authors: yan n. J Exp Med. 2017 Nov 6;214(11):3279-3292. doi: 10.1084/jem.20171351. Epub 2017 Sep 26. J Exp Med. 2017. PMID: 28951494 Free PMC article.

6

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.

Gonugunta VK, Sakai T, Pokatayev V, Yang K, Wu J, Dobbs N, Yan N. Gonugunta VK, et al. Among authors: yan n. Cell Rep. 2017 Dec 12;21(11):3234-3242. doi: 10.1016/j.celrep.2017.11.061. Cell Rep. 2017. PMID: 29241549 Free PMC article.

7

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.

Lu H, Fermaintt CS, Cherepanova NA, Gilmore R, Yan N, Lehrman MA. Lu H, et al. Among authors: yan n. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9557-9562. doi: 10.1073/pnas.1806034115. Epub 2018 Sep 4. Proc Natl Acad Sci U S A. 2018. PMID: 30181269 Free PMC article.

8

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.

Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N. Wu J, et al. Among authors: yan n. J Exp Med. 2019 Apr 1;216(4):867-883. doi: 10.1084/jem.20182192. Epub 2019 Mar 18. J Exp Med. 2019. PMID: 30886058 Free PMC article.

9

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.

Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N. Fermaintt CS, et al. Among authors: yan n. Nat Commun. 2019 May 30;10(1):2377. doi: 10.1038/s41467-019-10319-5. Nat Commun. 2019. PMID: 31147550 Free PMC article.

10

Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells.

Venkatadri R, Sabapathy V, Dogan M, Mohammad S, Harvey SE, Simpson SR, Grayson JM, Yan N, Perrino FW, Sharma R. Venkatadri R, et al. Among authors: yan n. Eur J Immunol. 2022 May;52(5):825-834. doi: 10.1002/eji.202149324. Epub 2022 Feb 15. Eur J Immunol. 2022. PMID: 35112355 Free PMC article.

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