Paiva AA - Search Results

1

Development, optimization and implementation of a centralized metabolic soft spot assay.

Paiva AA, Klakouski C, Li S, Johnson BM, Shu YZ, Josephs J, Zvyaga T, Zamora I, Shou WZ. Paiva AA, et al. Bioanalysis. 2017 Apr;9(7):541-552. doi: 10.4155/bio-2016-0299. Epub 2017 Mar 24. Bioanalysis. 2017. PMID: 28339283

2

Approach to improve compound recovery in a high-throughput Caco-2 permeability assay supported by liquid chromatography-tandem mass spectrometry.

Cai X, Walker A, Cheng C, Paiva A, Li Y, Kolb J, Herbst J, Shou W, Weller H. Cai X, et al. J Pharm Sci. 2012 Aug;101(8):2755-62. doi: 10.1002/jps.23194. Epub 2012 May 18. J Pharm Sci. 2012. PMID: 22611052

3

Recent developments in software tools for high-throughput in vitro ADME support with high-resolution MS.

Paiva A, Shou WZ. Paiva A, et al. Bioanalysis. 2016 Aug;8(16):1723-33. doi: 10.4155/bio-2016-0074. Epub 2016 Jul 20. Bioanalysis. 2016. PMID: 27487387 Review.

4

Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds.

Cai X, Madari S, Walker A, Paiva A, Li Y, Herbst J, Shou W, Weller H. Cai X, et al. SLAS Discov. 2019 Aug;24(7):738-744. doi: 10.1177/2472555219848483. Epub 2019 May 10. SLAS Discov. 2019. PMID: 31076010 Free article.

5

Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.

O'Malley DP, Ahuja V, Fink B, Cao C, Wang C, Swanson J, Wee S, Gavai AV, Tokarski J, Critton D, Paiva AA, Johnson BM, Szapiel N, Xie D. O'Malley DP, et al. Among authors: paiva aa. ACS Med Chem Lett. 2019 Sep 25;10(10):1486-1491. doi: 10.1021/acsmedchemlett.9b00354. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620238 Free PMC article.

6

Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay.

Cai X, Patel S, Huang C, Paiva A, Sun Y, Barker G, Weller H, Shou W. Cai X, et al. Xenobiotica. 2022 Jul;52(7):742-750. doi: 10.1080/00498254.2022.2133648. Epub 2022 Oct 13. Xenobiotica. 2022. PMID: 36217915

7

Development of a Predictive Multiple Reaction Monitoring (MRM) Model for High-Throughput ADME Analyses Using Learning-to-Rank (LTR) Techniques.

Adalia R, Patel S, Paiva A, Kaufman T, Zamora I, Cai X, Sanjuan G, Shou WZ. Adalia R, et al. J Am Soc Mass Spectrom. 2024 Jan 3;35(1):131-139. doi: 10.1021/jasms.3c00363. Epub 2023 Nov 28. J Am Soc Mass Spectrom. 2024. PMID: 38014625

8

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.

Wilson RJ, Jecs E, Miller EJ, Nguyen HH, Tahirovic YA, Truax VM, Kim MB, Kuo KM, Wang T, Sum CS, Cvijic ME, Paiva AA, Schroeder GM, Wilson LJ, Liotta DC. Wilson RJ, et al. Among authors: paiva aa. ACS Med Chem Lett. 2017 Dec 8;9(1):17-22. doi: 10.1021/acsmedchemlett.7b00381. eCollection 2018 Jan 11. ACS Med Chem Lett. 2017. PMID: 29348805 Free PMC article.

9

Intact Protein Mass Spectrometry of Cell Culture Harvest Guides Cell Line Development for Trispecific Antibodies.

Tousi F, Jiang Y, Sivendran S, Song Y, Elliott S, Paiva A, Lund A, Albee K, Lee K. Tousi F, et al. Anal Chem. 2020 Feb 4;92(3):2764-2769. doi: 10.1021/acs.analchem.9b05018. Epub 2020 Jan 24. Anal Chem. 2020. PMID: 31940175

10

Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes.

Mandler MD, Mignone J, Jurica EA, Palkowitz MD, Aulakh D, Cauley AN, Farley CA, Zhang S, Traeger SC, Sarjeant A, Paiva A, Perez HL, Ellsworth BA, Regueiro-Ren A. Mandler MD, et al. Org Lett. 2023 Nov 10;25(44):7947-7952. doi: 10.1021/acs.orglett.3c01417. Epub 2023 Jun 7. Org Lett. 2023. PMID: 37284784

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